(Q26829985)

title

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes (English)

1 reference

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Ajit Jadhav

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Anthony B Pinkerton

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Colleen B. Jonsson

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Tudor I Oprea

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

12

Joshua A Bittker

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

9

Larry A Sklar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1

Stuart L Schreiber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

31

Benjamin F Cravatt

1 reference

12 June 2020

Min Li

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Jeffrey Aubé

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Hugh Rosen

7

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Michelle Palmer

16

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Owen McManus

19

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Meng Wu

20

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Beiyan Zou

21

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Haibo Yu

22

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Edward Roberts

34

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Dong-Hoon Chung

35

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Subramaniam Ananthan

39

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Bruce Edwards

40

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Joanne D Kotz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Christopher P Austin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

John C Reed

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

E Lucile White

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Craig W Lindsley

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Benjamin R Alexander

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Paul A Clemons

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Andrea de Souza

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Michael A Foley

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Alykhan F Shamji

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Mathias J Wawer

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Frank J Schoenen

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Anton Simeonov

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Michael R Jackson

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Thomas D Y Chung

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Patrick R Griffin

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Peter S Hodder

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

William R Roush

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

James W Noah

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

William E Severson

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

P Jeffrey Conn

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Corey R Hopkins

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Michael R Wood

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Shaun R Stauffer

45

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Kyle A Emmitte

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

NIH Molecular Libraries Project Team

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

1 reference

4 June 2015

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

161

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

6

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

1252-1265

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

12 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Drug development: Raise standards for preclinical cancer research

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Crystal structure of a lipid G protein-coupled receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Drugs for allosteric sites on receptors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Functional discovery via a compendium of expression profiles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery of ML326: The first sub-micromolar, selective M5 PAM

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

7 April 2017

Too many roads not taken

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Multiplex cytological profiling assay to measure diverse cellular states

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

A crowdsourcing evaluation of the NIH chemical probes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Chemistry: Chemical con artists foil drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

HDX-MS guided drug discovery: small molecules and biopharmaceuticals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Treatment of lysosomal storage diseases: recent patents and future strategies.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Clinical development success rates for investigational drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Modulators of the Sphingosine 1-phosphate receptor 1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Validating therapeutic targets through human genetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

A sphingosine 1-phosphate receptor 2 selective allosteric agonist.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Sphingosine-1-phosphate and its receptors: structure, signaling, and influence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Determining target engagement in living systems

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Chaperone therapy update: Fabry disease, GM1-gangliosidosis and Gaucher disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Apolipoprotein e sets the stage: response to injury triggers neuropathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Novel selective allosteric and bitopic ligands for the S1P(3) receptor.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Antitrypanosomal therapy for chronic Chagas' disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

A fluopol-ABPP HTS assay to identify PAD inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Activity-based protein profiling for biochemical pathway discovery in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Probing the probes: fitness factors for small molecule tools

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The art of the chemical probe

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Modulating tone: the overture of S1P receptor immunotherapeutics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Integrating high-content screening and ligand-target prediction to identify mechanism of action

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Pyruvate kinase deficiency: the genotype-phenotype association.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

NIH Molecular Libraries Initiative

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The identification of myriocin-binding proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

An information-intensive approach to the molecular pharmacology of cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Microbiology. Eliminating malaria

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

The NIH's role in accelerating translational sciences

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Trial watch: Phase II failures: 2008-2010.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Phase III and submission failures: 2007–2010

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Fluid retention mediated by renal PPARgamma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4564295

Image-based multivariate profiling of drug responses from single cells

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26046436

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Preclinical target validation using patient-derived cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2015.05.023

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2015.05.023

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

release_qhfakmfeujh65fd5i7odkrunpa

12 June 2020

Fatcat ID

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26046436%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

26046436

2 references