(Q27005615)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

review article

2 references

8 February 2021

Redox control of glutamine utilization in cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

12 October 2019

nicotinamide adenine dinucleotide

1 reference

18 November 2019

1 reference

19 November 2019

1 reference

8 February 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

D Gaglio

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

language of work or name

1 reference

4 December 2014

8 references

3 April 2019

17 September 2019

12 October 2019

18 November 2019

19 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

8 February 2021

Cell Death and Disease

8 references

3 April 2019

17 September 2019

12 October 2019

18 November 2019

19 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

8 February 2021

5

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

e1561

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

24 February 2020

copyright license

6 references

3 April 2019

17 September 2019

12 October 2019

18 November 2019

19 November 2019

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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21 March 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 March 2017

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On the Origin of Cancer Cells

21 March 2017

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Targeting RAS signalling pathways in cancer therapy

22 April 2017

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RAS oncogenes: weaving a tumorigenic web

21 March 2017

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Proteome half-life dynamics in living human cells

21 March 2017

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 March 2017

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Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

21 March 2017

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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

21 March 2017

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Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma

21 March 2017

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 March 2017

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A community-driven global reconstruction of human metabolism.

7 April 2017

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MYC on the path to cancer

7 April 2017

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

7 April 2017

1 reference

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

7 April 2017

1 reference

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

7 April 2017

1 reference

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

7 April 2017

1 reference

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

7 April 2017

1 reference

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Serine catabolism regulates mitochondrial redox control during hypoxia

7 April 2017

1 reference

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A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

28 September 2017

1 reference

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The pentose phosphate pathway and cancer

28 September 2017

1 reference

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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

28 September 2017

1 reference

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13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells

28 September 2017

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Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

28 September 2017

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Quantitative flux analysis reveals folate-dependent NADPH production.

28 September 2017

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Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

28 September 2017

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

28 September 2017

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Metabolism addiction in pancreatic cancer

28 September 2017

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

28 September 2017

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Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis

28 September 2017

1 reference

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KRAS: feeding pancreatic cancer proliferation

28 September 2017

1 reference

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Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Tumor glycolysis as a target for cancer therapy: progress and prospects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

p73 regulates serine biosynthesis in cancer.

28 September 2017

1 reference

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Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Targeting lactate metabolism for cancer therapeutics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer.

28 September 2017

1 reference

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CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells

28 September 2017

1 reference

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A systems biology road map for the discovery of drugs targeting cancer cell metabolism.

28 September 2017

1 reference

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Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

28 September 2017

1 reference

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p63 regulates glutaminase 2 expression.

28 September 2017

1 reference

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Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure

28 September 2017

1 reference

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Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

28 September 2017

1 reference

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

13C metabolic flux analysis: optimal design of isotopic labeling experiments.

28 September 2017

1 reference

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Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Understanding metabolic regulation and its influence on cell physiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Profiling metabolic networks to study cancer metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

28 September 2017

1 reference

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Cellular metabolism and disease: what do metabolic outliers teach us?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Proline metabolism and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

28 September 2017

Cancer cell metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Metabolic flux and the regulation of mammalian cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

K-Ras and mitochondria: dangerous liaisons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Targeting cancer metabolism: a therapeutic window opens

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Mitochondrial complex I: a central regulator of the aging process.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Nampt: linking NAD biology, metabolism and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

ATP citrate lyase inhibition can suppress tumor cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Polyamines and cancer: old molecules, new understanding

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Breathless cancer cells get fat on glutamine

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

In silico experimentation with a model of hepatic mitochondrial folate metabolism.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Intracellular pathways of CD1 antigen presentation

31 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.513

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.513

Using multiple tracers for 13C metabolic flux analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.513

Visualization and quantification of cerebral metabolic fluxes of glucose in awake mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.513

Metabolic targets for cancer therapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454159

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

28 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.513

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2014.513

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25476909

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25476909%20AND%20SRC:MED&resulttype=core&format=json