(Q27015719)

30 June 2019

7 references

17 September 2019

19 September 2019

28 September 2019

18 November 2019

14 September 2020

27 September 2020

22 August 2022

Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents (English)

1 reference

30 June 2019

biomedical investigative technique

1 reference

17 September 2019

1 reference

19 September 2019

1 reference

28 September 2019

1 reference

18 November 2019

1 reference

14 September 2020

1 reference

27 September 2020

1

1 reference

30 June 2019

Giovanni Maga

object named as

Giovanni Maga

series ordinal

4

1 reference

ORCID Public Data File 2021

author name string

Anna Garbelli

series ordinal

2

1 reference

30 June 2019

Alessandra Amoroso

series ordinal

3

1 reference

30 June 2019

language of work or name

1 reference

16 September 2011

8 references

30 June 2019

17 September 2019

19 September 2019

28 September 2019

18 November 2019

14 September 2020

27 September 2020

22 August 2022

7 references

30 June 2019

17 September 2019

19 September 2019

28 September 2019

18 November 2019

14 September 2020

27 September 2020

16

1 reference

30 June 2019

issue

9

1 reference

30 June 2019

page(s)

7994-8019

1 reference

30 June 2019

Creative Commons Attribution

copyright license

7 references

17 September 2019

19 September 2019

28 September 2019

18 November 2019

14 September 2020

27 September 2020

22 August 2022

0 references

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

1 reference

12 December 2020

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

1 reference

12 December 2020

DNA polymerases and oxidative damage: friends or foes?

1 reference

12 December 2020

DNA polymerases as therapeutic targets

1 reference

12 December 2020

Modulation of the cellular metabolism of cytarabine and fludarabine by granulocyte-colony-stimulating factor during therapy of acute myelogenous leukemia.

1 reference

12 December 2020

Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities

1 reference

12 December 2020

DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress

1 reference

12 December 2020

Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions

1 reference

12 December 2020

1 reference

12 December 2020

Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis

1 reference

12 December 2020

Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases.

1 reference

12 December 2020

Poly(ADP-ribose) polymerase inhibitors

1 reference

12 December 2020

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

1 reference

12 December 2020

Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster

1 reference

12 December 2020

DNA replication and chemotherapy

1 reference

12 December 2020

Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair

1 reference

12 December 2020

Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2

1 reference

12 December 2020

The risk of malignant melanoma, internal malignancy and mortality in xeroderma pigmentosum patients

1 reference

12 December 2020

Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations

1 reference

12 December 2020

DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding.

1 reference

12 December 2020

CycloSal-BVDUMP pronucleotides: how to convert an antiviral-inactive nucleoside analogue into a bioactive compound against EBV.

1 reference

12 December 2020

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

1 reference

12 December 2020

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

12 December 2020

Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

1 reference

12 December 2020

A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells

1 reference

12 December 2020

The overexpression of specialized DNA polymerases in cancer.

1 reference

12 December 2020

Biological agents and gemcitabine in the treatment of breast cancer

1 reference

12 December 2020

Effect of a template-located 2',2'-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3'-->5'exonuclease-) fragment.

1 reference

12 December 2020

Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda

1 reference

12 December 2020

Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma

1 reference

12 December 2020

Excision of 2',2'-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA

1 reference

12 December 2020

Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells.

1 reference

12 December 2020

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

12 December 2020

Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia.

1 reference

12 December 2020

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

1 reference

12 December 2020

Gemcitabine as second-line treatment for advanced non-small-cell lung cancer: A phase II trial

1 reference

12 December 2020

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

1 reference

12 December 2020

Gemcitabine in hematologic malignancies

1 reference

12 December 2020

Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts

1 reference

12 December 2020

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens

1 reference

12 December 2020

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

12 December 2020

Genetics of natural populations; recombination and variability in populations of Drosophila pseudoobscura.

1 reference

12 December 2020

Phase I/II study of weekly paclitaxel plus carboplatin and gemcitabine as first-line treatment of advanced-stage ovarian cancer: pathologic complete response and longitudinal assessment of impact on cognitive functioning

1 reference

12 December 2020

Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study

1 reference

12 December 2020

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

1 reference

12 December 2020

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

1 reference

12 December 2020

Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases

1 reference

12 December 2020

Analysis of interactions of DNA polymerase beta and reverse transcriptases of human immunodeficiency and mouse leukemia viruses with dNTP analogs containing a modified sugar residue

1 reference

12 December 2020

The frameshift infidelity of human DNA polymerase lambda. Implications for function.

1 reference

12 December 2020

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent

1 reference

12 December 2020

5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine

1 reference

12 December 2020

Genetic factors influencing cytarabine therapy

1 reference

12 December 2020

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

1 reference

12 December 2020

Comparison of nanogel drug carriers and their formulations with nucleoside 5'-triphosphates

1 reference

12 December 2020

Modifications to the dNTP triphosphate moiety: from mechanistic probes for DNA polymerases to antiviral and anti-cancer drug design

1 reference

12 December 2020

Cellular pharmacology of gemcitabine

1 reference

12 December 2020

Ubiquitylation of DNA polymerase λ.

1 reference

12 December 2020

Eukaryotic DNA Polymerases

1 reference

12 December 2020

DNA polymerase lambda can elongate on DNA substrates mimicking non-homologous end joining and interact with XRCC4-ligase IV complex

1 reference

12 December 2020

The DNA-polymerase-X family: controllers of DNA quality?

1 reference

12 December 2020

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

1 reference

12 December 2020

Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and repairing DNA in proliferating human leukemia cells

1 reference

12 December 2020

Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside

1 reference

12 December 2020

Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers

1 reference

12 December 2020

Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations

1 reference

12 December 2020

A specific partner for abasic damage in DNA

1 reference

12 December 2020

Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase

1 reference

12 December 2020

New substrates of DNA polymerases

1 reference

12 December 2020

Minimum dose of fludarabine for the maximal modulation of 1-beta-D-arabinofuranosylcytosine triphosphate in human leukemia blasts during therapy

1 reference

12 December 2020

A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment

1 reference

12 December 2020

Nucleoside and nucleobase transport systems of mammalian cells

1 reference

12 December 2020

Antiviral drugs: current state of the art.

1 reference

12 December 2020

Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma

1 reference

12 December 2020

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

1 reference

12 December 2020

Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants

1 reference

12 December 2020

Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs

1 reference

12 December 2020

Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics

1 reference

12 December 2020

Pathway correcting DNA replication errors in Saccharomyces cerevisiae

1 reference

12 December 2020

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

1 reference

12 December 2020

Repair and translesion DNA polymerases as anticancer drug targets

1 reference

12 December 2020

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

1 reference

12 December 2020

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

1 reference

12 December 2020

The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

1 reference

12 December 2020

Bioreversible protection of nucleoside diphosphates

1 reference

12 December 2020

Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions

1 reference

12 December 2020

Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1.

1 reference

12 December 2020

Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues

1 reference

12 December 2020

Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta

1 reference

12 December 2020

DNA polymerase fidelity: kinetics, structure, and checkpoints

1 reference

12 December 2020

Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3'-deoxycytidine and 3'-azido-3'-deoxythymidine

1 reference

12 December 2020

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A

1 reference

12 December 2020

Phase II activity of gemcitabine in advanced breast cancer

1 reference

12 December 2020

Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides

1 reference

12 December 2020

Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance

1 reference

12 December 2020

Instability and decay of the primary structure of DNA

1 reference

12 December 2020

Fludarabine infusion potentiates arabinosylcytosine metabolism in lymphocytes of patients with chronic lymphocytic leukemia

1 reference

12 December 2020

Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.

1 reference

12 December 2020

Response of human DNA polymerase iota to DNA lesions

1 reference

12 December 2020

Evidence of finely tuned expression of DNA polymerase beta in vivo using transgenic mice

1 reference

12 December 2020

Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle

1 reference

12 December 2020

Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia

1 reference

12 December 2020

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.

1 reference

12 December 2020

The Li-Fraumeni syndrome

1 reference

12 December 2020

Integrating genetic approaches into the discovery of anticancer drugs

1 reference

12 December 2020

The Efficiency and Fidelity of Translesion Synthesis past Cisplatin and Oxaliplatin GpG Adducts by Human DNA Polymerase β

1 reference

12 December 2020

An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda

1 reference

12 December 2020

Targeting the double-strand DNA break repair pathway as a therapeutic strategy

1 reference

12 December 2020

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

1 reference

12 December 2020

Alteration of the pharmacokinetics of high-dose ara-C by its metabolite, high ara-U in patients with acute leukemia

1 reference

12 December 2020

Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda.

1 reference

12 December 2020

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

12 December 2020

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

1 reference

12 December 2020

The 5'-nucleotidases as regulators of nucleotide and drug metabolism

1 reference

12 December 2020

Nucleoside transport in normal and neoplastic cells

1 reference

12 December 2020

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

1 reference

12 December 2020

8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha

1 reference

12 December 2020

DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin

1 reference

12 December 2020

Interaction between DNA Polymerase and Anticancer Nucleoside Analogs

1 reference

12 December 2020

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs

1 reference

12 December 2020

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

1 reference

12 December 2020

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

1 reference

12 December 2020

Gamma-phosphate-substituted 2'-deoxynucleoside 5'-triphosphates as substrates for DNA polymerases

1 reference

12 December 2020

The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond

1 reference

12 December 2020

The genetic and molecular basis of Fanconi anemia

1 reference

12 December 2020

Genome maintenance mechanisms for preventing cancer

1 reference

12 December 2020

10.3390/MOLECULES16097994

Identifiers

DOI

1 reference

30 June 2019

PMCID

6264456

1 reference

30 June 2019

PubMed ID

21926946

1 reference

30 June 2019