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Status of PI3K/Akt/mTOR pathway inhibitors in lymphoma
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PubMed
review article
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Europe PubMed Central
title
Status of PI3K/Akt/mTOR pathway inhibitors in lymphoma
(English)
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author
Jason R Westin
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object named as
Jason R. Westin
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Crossref
language of work or name
English
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stated in
PubMed
publication date
October 2014
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stated in
PubMed
published in
Clinical Lymphoma, Myeloma & Leukemia
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stated in
PubMed
volume
14
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stated in
PubMed
issue
5
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stated in
PubMed
page(s)
335-42
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PubMed
cites work
A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma
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AKT/PKB signaling: navigating downstream
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21 March 2017
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
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21 March 2017
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
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21 March 2017
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
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PubMed Central
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21 March 2017
The phosphoinositide (PI) 3-kinase family
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PubMed Central
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21 March 2017
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
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21 March 2017
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
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PubMed Central
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21 March 2017
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
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21 March 2017
PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma
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PubMed Central
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21 March 2017
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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PubMed Central
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21 March 2017
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
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PubMed Central
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21 March 2017
Upstream and downstream of mTOR
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21 March 2017
The biology and clinical relevance of the PTEN tumor suppressor pathway
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21 March 2017
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis
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PubMed Central
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21 March 2017
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
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PubMed Central
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21 March 2017
PI 3-kinase p110beta: a new target for antithrombotic therapy
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PubMed Central
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21 March 2017
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation
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21 March 2017
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
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PubMed Central
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7 April 2017
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
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PubMed Central
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7 April 2017
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
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PubMed Central
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7 April 2017
PI3K pathway alterations in cancer: variations on a theme
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PubMed Central
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7 April 2017
mTOR and cancer: insights into a complex relationship
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PubMed Central
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7 April 2017
Exploiting the PI3K/AKT pathway for cancer drug discovery
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PubMed Central
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7 April 2017
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
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PubMed Central
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7 April 2017
Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations
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28 September 2017
Phase I study of panobinostat plus everolimus in patients with relapsed or refractory lymphoma
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PubMed Central
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28 September 2017
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
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PubMed Central
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28 September 2017
Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease--a combined tissue microarray, in vitro and in vivo study
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PubMed Central
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28 September 2017
Phase I study of ON 01910.Na (Rigosertib), a multikinase PI3K inhibitor in relapsed/refractory B-cell malignancies
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PubMed Central
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28 September 2017
P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse
1 reference
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PubMed Central
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28 September 2017
PAK1 mediates resistance to PI3K inhibition in lymphomas.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
It's about time: lessons for solid tumors from chronic myelogenous leukemia therapy
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PubMed Central
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28 September 2017
Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities
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PubMed Central
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28 September 2017
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
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PubMed Central
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28 September 2017
Inhibitors of B-cell receptor signaling for patients with B-cell malignancies
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PubMed Central
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28 September 2017
Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
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PubMed Central
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28 September 2017
Personalized oncology through integrative high-throughput sequencing: a pilot study
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PubMed Central
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28 September 2017
The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence
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28 September 2017
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium
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PubMed Central
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28 September 2017
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
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PubMed Central
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28 September 2017
Protein dynamics in drug combinations: a linear superposition of individual-drug responses
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PubMed Central
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28 September 2017
The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Mutations of the PIK3CA gene in diffuse large B cell lymphoma
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Oncogenic PI3K deregulates transcription and translation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Advances in protein kinase B signalling: AKTion on multiple fronts
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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28 September 2017
The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
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31 May 2018
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
retrieved
31 May 2018
Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
retrieved
28 November 2018
Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
retrieved
28 November 2018
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
retrieved
28 November 2018
Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
retrieved
28 November 2018
Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125533
retrieved
28 November 2018
Preliminary results of a phase II study of single agent Bay 80-6946, a Novel PI3K inhibitor, in patients with relapsed/refractory, indolent or aggressive lymphoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24650973
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24650973
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phosphorylated AKT protein is overexpressed in human peripheral T-cell lymphomas and predicts decreased patient survival
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24650973
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CLML.2014.01.007
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4885785
OpenCitations bibliographic resource ID
4885785
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4885785
PMC publication ID
4125533
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4885785
PubMed publication ID
24650973
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4885785
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