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AID targeting is dependent on RNA polymerase II pausing
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title
AID targeting is dependent on RNA polymerase II pausing
(English)
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stated in
PubMed
author name string
Kenter AL
series ordinal
1
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stated in
PubMed
publication date
August 2012
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stated in
PubMed
published in
Seminars in Immunology
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stated in
PubMed
volume
24
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stated in
PubMed
issue
4
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stated in
PubMed
page(s)
281-6
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PubMed
cites work
CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
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PubMed Central
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20 March 2017
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
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PubMed Central
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20 March 2017
c-Myc regulates transcriptional pause release
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PubMed Central
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20 March 2017
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1
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PubMed Central
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20 March 2017
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
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PubMed Central
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20 March 2017
Somatic hypermutation of the AID transgene in B and non-B cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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20 March 2017
Transcriptional consequences of topoisomerase inhibition
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20 March 2017
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
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PubMed Central
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20 March 2017
Transcription elongation factor hSPT5 stimulates mRNA capping
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PubMed Central
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20 March 2017
High-resolution profiling of histone methylations in the human genome
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PubMed Central
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20 March 2017
The role of chromatin during transcription
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PubMed Central
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20 March 2017
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
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PubMed Central
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20 March 2017
The complex language of chromatin regulation during transcription
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20 March 2017
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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20 March 2017
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
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PubMed Central
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20 March 2017
The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter
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PubMed Central
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20 March 2017
Capturing chromosome conformation
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PubMed Central
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20 March 2017
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
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20 March 2017
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
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20 March 2017
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
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PubMed Central
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20 March 2017
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination
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PubMed Central
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20 March 2017
A chromatin landmark and transcription initiation at most promoters in human cells
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7 April 2017
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
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PubMed Central
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7 April 2017
Functions of site-specific histone acetylation and deacetylation
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7 April 2017
Genome-wide map of nucleosome acetylation and methylation in yeast
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7 April 2017
Genomic maps and comparative analysis of histone modifications in human and mouse
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7 April 2017
AID targeting in antibody diversity
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PubMed Central
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29 September 2017
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.
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29 September 2017
Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells
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29 September 2017
Pause locally, splice globally
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PubMed Central
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29 September 2017
Signals and combinatorial functions of histone modifications
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29 September 2017
Complex regulation and function of activation-induced cytidine deaminase
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29 September 2017
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
1 reference
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PubMed Central
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29 September 2017
Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination
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PubMed Central
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29 September 2017
AID and somatic hypermutation.
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PubMed Central
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29 September 2017
GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.
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PubMed Central
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29 September 2017
Attracting AID to targets of somatic hypermutation
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PubMed Central
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29 September 2017
Modifications of RNA polymerase II are pivotal in regulating gene expression states
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PubMed Central
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29 September 2017
Defining mechanisms that regulate RNA polymerase II transcription in vivo
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PubMed Central
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29 September 2017
S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination
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PubMed Central
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29 September 2017
Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.
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PubMed Central
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29 September 2017
Ikaros controls isotype selection during immunoglobulin class switch recombination
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PubMed Central
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29 September 2017
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
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PubMed Central
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29 September 2017
Control of histone methylation and genome stability by PTIP
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PubMed Central
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29 September 2017
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
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PubMed Central
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29 September 2017
A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation
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PubMed Central
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29 September 2017
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus
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29 September 2017
Hijacked DNA repair proteins and unchained DNA polymerases
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PubMed Central
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29 September 2017
Mapping cis- and trans- chromatin interaction networks using chromosome conformation capture (3C).
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29 September 2017
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development
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PubMed Central
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29 September 2017
Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein.
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29 September 2017
Mechanism and regulation of class switch recombination
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PubMed Central
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29 September 2017
The biochemistry of somatic hypermutation
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29 September 2017
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
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PubMed Central
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29 September 2017
RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.
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29 September 2017
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase
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PubMed Central
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29 September 2017
Evidence for physical interaction between the immunoglobulin heavy chain variable region and the 3' regulatory region
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates
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PubMed Central
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29 September 2017
Immunoglobulin somatic hypermutation
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PubMed Central
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29 September 2017
Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region
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PubMed Central
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29 September 2017
Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection
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PubMed Central
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29 September 2017
Evolution of the immunoglobulin heavy chain class switch recombination mechanism
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PubMed Central
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29 September 2017
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
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PubMed Central
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29 September 2017
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
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PubMed Central
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29 September 2017
Targeting of AID to immunoglobulin genes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Molecular mechanisms of antibody somatic hypermutation.
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29 September 2017
Breaking barriers to transcription elongation
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29 September 2017
Class switch recombination: an emerging mechanism.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
AID-dependent histone acetylation is detected in immunoglobulin S regions
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Control of transcription through intragenic patterns of nucleosome composition
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PubMed Central
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29 September 2017
Inducible DNA breaks in Ig S regions are dependent on AID and UNG
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
Transcription through chromatin: understanding a complex FACT.
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PubMed Central
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29 September 2017
Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination
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29 September 2017
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation
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29 September 2017
AID mediates hypermutation by deaminating single stranded DNA.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
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29 September 2017
The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Mechanism and control of class-switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Mechanisms of chromosomal translocations in B cell lymphomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Increased transcription levels induce higher mutation rates in a hypermutating cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Higher-order structure of chromatin and chromosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
RNA polymerase II elongation through chromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Molecular processes that regulate class switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Processing of switch transcripts is required for targeting of antibody class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Molecular aspects of heavy-chain class switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
29 September 2017
Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
2 June 2018
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
2 June 2018
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
2 June 2018
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
2 June 2018
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
2 June 2018
Histone modification: cause or cog?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Isolation of a sequence-specific RNA binding protein, polypyrimidine tract binding protein, using RNA affinity chromatography
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Two levels of protection for the B cell genome during somatic hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Transcription-coupled events associating with immunoglobulin switch region chromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Constitutive expression of AID leads to tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Somatic hypermutation in the heavy chain locus correlates with transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630797
retrieved
27 November 2018
Switch transcripts in immunoglobulin class switching
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ig S gamma-specific DNA binding protein SNAP is related to the helix-loop-helix transcription factor E47
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impairment of transcription elongation by R-loops in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The influence of transcriptional orientation on endogenous switch region function
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22784681
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.SMIM.2012.06.001
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4823074
OpenCitations bibliographic resource ID
4823074
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4823074
PMC publication ID
3630797
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4823074
PubMed publication ID
22784681
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4823074
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