(Q28083809)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

review article

1 reference

title

Engineering enhanced protein disaggregases for neurodegenerative disease (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

4 references

25 April 2019

20 June 2019

3 August 2019

19 September 2019

1 reference

3 August 2019

biomedical investigative technique

1 reference

19 September 2019

macromolecular substance

1 reference

16 November 2019

1 reference

13 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

James Shorter

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

Meredith E Jackrel

series ordinal

1

1 reference

James Shorter

series ordinal

2

1 reference

language of work or name

1 reference

1 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

8 references

25 April 2019

20 June 2019

3 August 2019

19 September 2019

16 November 2019

13 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

9

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

90-109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 3.0 Unported

2 March 2020

copyright license

6 references

25 April 2019

20 June 2019

3 August 2019

19 September 2019

16 November 2019

on focus list of Wikimedia project

13 December 2019

ScienceSource

0 references

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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

20 March 2017

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20 March 2017

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20 March 2017

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

20 March 2017

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Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

20 March 2017

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

20 March 2017

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

7 April 2017

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

7 April 2017

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Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

7 April 2017

1 reference

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The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation

7 April 2017

1 reference

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Alpha-synuclein function and dysfunction on cellular membranes

29 September 2017

1 reference

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Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

29 September 2017

1 reference

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Isolating potentiated Hsp104 variants using yeast proteinopathy models

29 September 2017

1 reference

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Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis

29 September 2017

1 reference

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Combating neurodegenerative disease with chemical probes and model systems

29 September 2017

1 reference

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Calcineurin determines toxic versus beneficial responses to α-synuclein

29 September 2017

1 reference

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Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

29 September 2017

1 reference

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Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

29 September 2017

1 reference

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Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly.

29 September 2017

1 reference

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Proteostasis impairment in protein-misfolding and -aggregation diseases

29 September 2017

1 reference

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The amyloid state and its association with protein misfolding diseases.

29 September 2017

1 reference

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The Surprising Role of Amyloid Fibrils in HIV Infection

29 September 2017

1 reference

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Reversing deleterious protein aggregation with re-engineered protein disaggregases.

29 September 2017

1 reference

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Hsp104 overexpression cures Saccharomyces cerevisiae [PSI+] by causing dissolution of the prion seeds

29 September 2017

1 reference

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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

29 September 2017

1 reference

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

29 September 2017

1 reference

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Super Spy variants implicate flexibility in chaperone action

29 September 2017

1 reference

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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Biology and genetics of prions causing neurodegeneration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

α-Synucleinopathy phenotypes

29 September 2017

1 reference

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Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

29 September 2017

1 reference

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Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Fission yeast does not age under favorable conditions, but does so after stress.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

29 September 2017

1 reference

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Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Stress granules as crucibles of ALS pathogenesis.

29 September 2017

1 reference

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Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The changing scene of amyotrophic lateral sclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Evidence-based review and assessment of botulinum neurotoxin for the treatment of urologic conditions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Aneuploidy causes proteotoxic stress in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Botulinum neurotoxins: mechanism of action.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)].

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Tafamidis for transthyretin amyloidosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The amyloid state of proteins in human diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Prions are a common mechanism for phenotypic inheritance in wild yeasts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A yeast functional screen predicts new candidate ALS disease genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

RNA-binding proteins with prion-like domains in ALS and FTLD-U.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The elusive middle domain of Hsp104 and ClpB: location and function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Single methyl group determines prion propagation and protein degradation activities of yeast heat shock protein (Hsp)-70 chaperones Ssa1p and Ssa2p

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Model organisms reveal insight into human neurodegenerative disease: ataxin-2 intermediate-length polyglutamine expansions are a risk factor for ALS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A yeast model of FUS/TLS-dependent cytotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Heat shock protein 104 inhibited the fibrillization of prion peptide 106-126 and disassembled prion peptide 106-126 fibrils in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The prion hypothesis: from biological anomaly to basic regulatory mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The M-domain controls Hsp104 protein remodeling activity in an Hsp70/Hsp40-dependent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

α-Synuclein: membrane interactions and toxicity in Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Emergence and natural selection of drug-resistant prions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Prion-like disorders: blurring the divide between transmissibility and infectivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

TAR DNA-binding protein 43 in neurodegenerative disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Applying Hsp104 to protein-misfolding disorders.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The TET family of proteins: functions and roles in disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Motor mechanism for protein threading through Hsp104.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Prion proteostasis: Hsp104 meets its supporting cast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

TDP-43 A315T mutation in familial motor neuron disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Hsp104: a weapon to combat diverse neurodegenerative disorders.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Beer and bread to brains and beyond: can yeast cells teach us about neurodegenerative disease?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Functional amyloid--from bacteria to humans.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The Janus faces of botulinum neurotoxin: sensational medicine and deadly biological weapon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A century of Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Infection by ME7 prion is not modified in transgenic mice expressing the yeast chaperone Hsp104 in neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A network of protein interactions determines polyglutamine toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A possible epigenetic mechanism for the persistence of memory

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A neuronal isoform of the aplysia CPEB has prion-like properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Hsp104 is required for tolerance to many forms of stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

A systematic evaluation of the function of the protein-remodeling factor Hsp104 in [PSI+] prion propagation in S. cerevisiae by comprehensive chromosomal mutations

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Peptide and protein binding in the axial channel of Hsp104. Insights into the mechanism of protein unfolding

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

PENN neurodegenerative disease research - in the spirit of Benjamin Franklin.

2 June 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Two Parkinson's disease patients with alpha-synuclein gene duplication and rapid cognitive decline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

alpha-Synuclein gene duplication is present in sporadic Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

A tightly regulated molecular toggle controls AAA+ disaggregase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Directed evolution of the DnaK chaperone: mutations in the lid domain result in enhanced chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Fine tuning of a biological machine: DnaK gains improved chaperone activity by altered allosteric communication and substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Epigenetics in the Extreme: Prions and the Inheritance of Environmentally Acquired Traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Directed evolution of substrate-optimized GroEL/S chaperonins

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601286

Tafamidis (Vyndaqel): A Light for FAP Patients

27 November 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19336896.2015.1020277

From yeast to patient neurons and back again: powerful new discovery platform

21 January 2018

1 reference

12 December 2020

An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry

1 reference

12 December 2020

Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes

1 reference

12 December 2020

Hsp104 gives clients the individual attention they need

1 reference

12 December 2020

10.1080/19336896.2015.1020277

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25738979%20AND%20SRC:MED&resulttype=core&format=json