(Q28209980)

reason for preferred rank

23 March 2017

Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1⋅TSC2 Complex (English)

most precise value

0 references

Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

signal transducing adaptor protein

21 March 2024

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

Drosophila proteins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

21 March 2024

author name string

Vanishree Murthy

1

0 references

Sangyeul Han

2

0 references

Nicole Smith

4

0 references

Naoto Ito

6

0 references

Vijaya Ramesh

7

0 references

Roberta L. Beauchamp

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

Luciana A. Haddad

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

21 March 2024

language of work or name

English

0 references

publication date

9 January 2004

0 references

14 October 2003

1 reference

full work available at URL

23 March 2017

http://www.jbc.org/article/S0021925818527496/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14559897

https://api.elsevier.com/content/article/PII:S0021925818527496?httpAccept=text/xml

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

https://api.elsevier.com/content/article/PII:S0021925818527496?httpAccept=text/plain

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

https://syndication.highwire.org/content/doi/10.1074/jbc.M310208200

21 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

Journal of Biological Chemistry

21 March 2024

published in

1 reference

23 March 2017

volume

279

1 reference

23 March 2017

issue

2

1 reference

23 March 2017

page(s)

1351-8

0 references

1351-1358

1 reference

Identification and characterization of the tuberous sclerosis gene on chromosome 16

23 March 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Identification of a large Myc-binding protein that contains RCC1-like repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Highwire regulates synaptic growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Understanding gene and allele function with two-hybrid methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Developmental expression of PAM (protein associated with MYC) in the rodent brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Protein associated with Myc (PAM) is a potent inhibitor of adenylyl cyclases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

RING finger proteins: mediators of ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Ubiquitination-dependent mechanisms regulate synaptic growth and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310208200

21 January 2018

5

59

1206

Kobayashi

1999

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200

21 March 2024

18

62

5645

Kenerson

2002

1 reference

https://api.crossref.org/works/10.1074/JBC.M310208200