(Q28248627)

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Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies

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Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies (English)

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Philip C Simister

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Stephan M Feller

2

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January 2012

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Molecular BioSystems

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8

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1

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33-46

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Function, regulation and pathological roles of the Gab/DOS docking proteins

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Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

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CAS proteins in normal and pathological cell growth control

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21 January 2018

Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2

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21 January 2018

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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21 January 2018

Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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The "Gab" in signal transduction.

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21 January 2018

The gift of Gab.

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21 January 2018

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

1 reference

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21 January 2018

Essential role of Gab1 for signaling by the c-Met receptor in vivo

1 reference

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21 January 2018

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

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21 January 2018

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent

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Essential role for Gab2 in the allergic response

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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

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Abnormal hematopoiesis in Gab2 mutant mice

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Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

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Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

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Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

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Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.

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Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis

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21 January 2018

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

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The Pfam protein families database

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SMART 6: recent updates and new developments

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Self-organization and regulation of intrinsically disordered proteins with folded N-termini

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21 January 2018

ELM: the status of the 2010 eukaryotic linear motif resource

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Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions

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21 January 2018

Protein structure prediction servers at University College London

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Proteins without 3D structure: definition, detection and beyond

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The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome

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Sequence complexity of disordered protein

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RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins

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Prediction of disordered regions in proteins based on the meta approach

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PONDR-FIT: a meta-predictor of intrinsically disordered amino acids

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Improved disorder prediction by combination of orthogonal approaches

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Flavors of protein disorder

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A new mechanism for the regulation of Gab1 recruitment to the plasma membrane.

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Close encounters of the third kind: disordered domains and the interactions of proteins.

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The consensus coding sequences of human breast and colorectal cancers

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Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms

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Prediction of protein binding regions in disordered proteins

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Intrinsic disorder in scaffold proteins: getting more from less

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The structure of "unstructured" regions in peptides and proteins: role of the polyproline II helix in protein folding and recognition

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A tetrapeptide-based method for polyproline II-type secondary structure prediction

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Context-dependent resistance to proteolysis of intrinsically disordered proteins

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The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal

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Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.

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p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

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A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor

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Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

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Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility

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Grb2 is a key mediator of helicobacter pylori CagA protein activities

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Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

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Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells

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A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.

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Purpose of recently detected inhibitory domain of the Helicobacter pylori protein CagA.

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Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase

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Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates

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Gab2-mediated signaling promotes melanoma metastasis

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