(Q28256875)

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Presenilins are not required for A beta 42 production in the early secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

BACE1 interacts with nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312710200