(Q42049875)

15 October 2017

Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells (English)

1 reference

15 October 2017

Pascal Kienlen-Campard

series ordinal

2

object named as

Pascal Kienlen-Campard

1 reference

15 October 2017

Didier Pitsi

1

1 reference

PubMed ID

12423249

15 October 2017

Jean-Noël Octave

series ordinal

3

1 reference

PubMed ID

12423249

15 October 2017

language of work or name

English

0 references

publication date

1 October 2002

1 reference

Journal of Neurochemistry

15 October 2017

1 reference

15 October 2017

83

1 reference

15 October 2017

2

1 reference

15 October 2017

390-399

1 reference

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

15 October 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

The multiple paradoxes of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Recombinational construction in Escherichia coli of infectious adenoviral genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Baculovirus-infected cells do not produce the amyloid peptide of Alzheimer's disease from its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Nucleotide sequence of the chromosome 14-encodedS182cDNA and revised secondary structure prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Widespread long-term gene transfer to mouse skeletal muscles and heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilin and gamma-secretase: structure meets function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Abnormal gel-electrophoretic behavior of presenilin 1 and it's fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

A novel substrate for analyzing Alzheimer's disease gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01138.X

10.1046/J.1471-4159.2002.01138.X

21 January 2018

Identifiers

DOI

1 reference

15 October 2017

1 reference

PubMed ID

12423249