(Q28299046)

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.

21 January 2018

1 reference

The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

21 January 2018

1 reference

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

21 January 2018

1 reference

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

21 January 2018

1 reference

Apoptosis - the p53 network

21 January 2018

1 reference

p53 has a direct apoptogenic role at the mitochondria

31 March 2020

1 reference

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

31 March 2020

1 reference

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

1 reference

Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations

31 March 2020

1 reference

p53: a heavily dictated dictator of life and death

31 March 2020

1 reference

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

31 March 2020

1 reference

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

1 reference

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

31 March 2020

1 reference

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

1 reference

A novel cofactor for p300 that regulates the p53 response

31 March 2020

1 reference

ASPP proteins specifically stimulate the apoptotic function of p53

31 March 2020

1 reference

Two cellular proteins that bind to wild-type but not mutant p53

31 March 2020

1 reference

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

31 March 2020

1 reference

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

31 March 2020

1 reference

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

31 March 2020

1 reference

Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53

31 March 2020

1 reference

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

31 March 2020

1 reference

Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor

31 March 2020

1 reference

ASPP2 inhibits APP‐BP1‐mediated NEDD8 conjugation to cullin‐1 and decreases APP‐BP1‐induced cell proliferation and neuronal apoptosis

31 March 2020

1 reference

Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains

31 March 2020

1 reference

Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis

31 March 2020

1 reference

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro

31 March 2020

1 reference

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization.

31 March 2020

1 reference

A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice

31 March 2020

1 reference

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

31 March 2020

1 reference

Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing

31 March 2020

1 reference

NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2

31 March 2020

1 reference

Gene expression changes in response to E2F1 activation.

31 March 2020

1 reference

ASPP1 and ASPP2 are new transcriptional targets of E2F

31 March 2020

1 reference

Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.

31 March 2020

1 reference

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53

31 March 2020

1 reference

Control of ASPP2/(53BP2L) protein levels by proteasomal degradation modulates p53 apoptotic function

31 March 2020

1 reference

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

31 March 2020

1 reference

ASPP1 and ASPP2: common activators of p53 family members

31 March 2020

1 reference

DeltaNp53 or p44: priming the p53 pump.

31 March 2020

1 reference

Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis.

31 March 2020

1 reference

53BP2 induces apoptosis through the mitochondrial death pathway

31 March 2020

1 reference

Of flies and men; p53, a tumour suppressor

31 March 2020

1 reference

Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans

31 March 2020

1 reference

Modulation of mammalian life span by the short isoform of p53.

31 March 2020

1 reference

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

31 March 2020

1 reference

Drosophila p53 preserves genomic stability by regulating cell death

31 March 2020

1 reference

Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae

31 March 2020

1 reference

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

31 March 2020

1 reference

p53 isoforms can regulate p53 transcriptional activity.

31 March 2020

1 reference

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

1 reference

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

31 March 2020

1 reference

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

31 March 2020

1 reference

p63 is a p53 homologue required for limb and epidermal morphogenesis

31 March 2020

1 reference

On the shoulders of giants: p63, p73 and the rise of p53.

31 March 2020

1 reference

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

31 March 2020

1 reference

Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines

31 March 2020

1 reference

p53-interacting protein 53BP2 inhibits clonogenic survival and sensitizes cells to doxorubicin but not paclitaxel-induced apoptosis

31 March 2020

1 reference

p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma

31 March 2020

1 reference

Abnormal mRNA expression of ASPP members in leukemia cell lines.

31 March 2020

1 reference

ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia.

31 March 2020

1 reference

Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53

31 March 2020

1 reference

Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome

31 March 2020

1 reference

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

31 March 2020

1 reference

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

1 reference

Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins

31 March 2020

1 reference