(Q28504452)

24 January 2017

title

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366 (English)

1 reference

Serine/threonine kinase 11

24 January 2017

0 references

1 reference

GOA release 2020-03-11

ataxia telangiectasia

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2

Maria Deak

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author name string

Gopal P. Sapkota

1

1 reference

24 January 2017

Agnieszka Kieloch

3

1 reference

24 January 2017

Nick Morrice

4

1 reference

24 January 2017

Aaron A. Goodarzi

5

1 reference

24 January 2017

Carl Smythe

6

1 reference

24 January 2017

Yosef Shiloh

7

1 reference

24 January 2017

Susan P. Lees-Miller

8

1 reference

24 January 2017

Dario R. Alessi

9

1 reference

24 January 2017

language of work or name

English

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publication date

1 December 2002

1 reference

24 January 2017

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24 January 2017

volume

368

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24 January 2017

issue

Pt 2

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24 January 2017

page(s)

507–516

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LKB1--a master tumour suppressor of the small intestine and beyond

24 January 2017

cites work

1 reference

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Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

19 March 2017

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

19 March 2017

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LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

19 March 2017

1 reference

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ATM: genome stability, neuronal development, and cancer cross paths

19 March 2017

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

19 March 2017

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LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

19 March 2017

1 reference

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

19 March 2017

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

19 March 2017

1 reference

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

19 March 2017

1 reference

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

19 March 2017

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

19 March 2017

1 reference

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The PI3K-PDK1 connection: more than just a road to PKB

19 March 2017

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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

19 March 2017

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19 March 2017

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Substrate specificities and identification of putative substrates of ATM kinase family members

29 September 2017

1 reference

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The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

19 March 2017

1 reference

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Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

19 March 2017

1 reference

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

19 March 2017

1 reference

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

19 March 2017

1 reference

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

19 March 2017

1 reference

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

19 March 2017

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

19 March 2017

1 reference

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

7 April 2017

1 reference

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Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

29 September 2017

1 reference

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Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice

29 September 2017

1 reference

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Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

29 September 2017

1 reference

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Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

29 September 2017

1 reference

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Interferon regulatory factor-3 is an in vivo target of DNA-PK.

29 September 2017

1 reference

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Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p

29 September 2017

1 reference

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Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma

29 September 2017

1 reference

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

29 September 2017

1 reference

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Detection of DNA-dependent protein kinase in extracts from human and rodent cells

29 September 2017

1 reference

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Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

The molecular basis and clinical aspects of Peutz-Jeghers syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Peutz-Jeghers syndrome: 78-year follow-up of the original family

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Mutations of the STK11 gene in sporadic gastric carcinoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Recombinant ATM protein complements the cellular A-T phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

DNA damage and the DNA-activated protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

The genetic defect in ataxia-telangiectasia

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223019

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2 June 2018

1 reference

12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

12 December 2020

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

1 reference

12 December 2020

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1 reference

12 December 2020

Identifiers

1 reference

24 January 2017

0 references

1 reference