(Q30179454)

9 June 2017

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators (English)

1 reference

Glucagon like peptide 1 receptor

9 June 2017

transmembrane protein

0 references

1 reference

glucagon-like peptide 1 receptor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Qingtong Zhou

5

0 references

Suwen Zhao

Suwen Zhao

14

0 references

Chris de Graaf

Chris de Graaf

4

0 references

Raymond C. Stevens

Raymond C Stevens

22

0 references

Antao Dai

9

Antao Dai

1 reference

9 June 2017

16

Gye Won Han

1 reference

9 June 2017

19

Michael A Hanson

1 reference

9 June 2017

Gaojie Song

1

1 reference

9 June 2017

Dehua Yang

2

1 reference

9 June 2017

Yuxia Wang

3

1 reference

9 June 2017

Shanshan Jiang

6

1 reference

9 June 2017

Kaiwen Liu

7

1 reference

9 June 2017

Xiaoqing Cai

8

1 reference

9 June 2017

Guangyao Lin

10

1 reference

9 June 2017

Dongsheng Liu

11

1 reference

9 June 2017

Fan Wu

12

1 reference

9 June 2017

Yiran Wu

13

1 reference

9 June 2017

Li Ye

15

1 reference

9 June 2017

Jesper Lau

17

1 reference

9 June 2017

Beili Wu

18

1 reference

9 June 2017

Zhi-Jie Liu

20

1 reference

9 June 2017

Ming-Wei Wang

21

1 reference

9 June 2017

language of work or name

English

0 references

publication date

17 May 2017

1 reference

9 June 2017

1 reference

Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes

9 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Targeting the glucagon receptor family for diabetes and obesity therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Extra-helical binding site of a glucagon receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Crystal structure of the β2 adrenergic receptor-Gs protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Structure of the adenosine A(2A) receptor bound to an engineered G protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Crystal structure of opsin in its G-protein-interacting conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Small-molecule agonists for the glucagon-like peptide 1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Structure of class B GPCR corticotropin-releasing factor receptor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Structure of the human glucagon class B G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Two disparate ligand-binding sites in the human P2Y1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

New beta-alanine derivatives are orally available glucagon receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Insights into the structure of class B GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Molecular signatures of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

In vitro expression and analysis of the 826 human G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Features and development of Coot

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Docking covalent inhibitors: a parameter free approach to pose prediction and scoring.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Extension of the CHARMM General Force Field to sulfonyl-containing compounds and its utility in biomolecular simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Canonical sampling through velocity rescaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

FreeSASA: An open source C library for solvent accessible surface area calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

Structure of the full-length glucagon class B G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

inferred from DOI database lookup

7 January 2021

based on heuristic

Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop

1 reference

https://api.crossref.org/works/10.1038%2FNATURE22378

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE22378

1 reference

9 June 2017

1 reference