(Q30353164)

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Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.

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scholarly article

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Europe PubMed Central

2 November 2017

Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study. (English)

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Europe PubMed Central

2 November 2017

Gennady Verkhivker

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Gennady M Verkhivker

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Kristin Blacklock

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Europe PubMed Central

2 November 2017

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19 August 2013

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Europe PubMed Central

2 November 2017

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Europe PubMed Central

2 November 2017

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Europe PubMed Central

2 November 2017

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Europe PubMed Central

2 November 2017

e71936

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Europe PubMed Central

2 November 2017

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Creative Commons Attribution 4.0 International

19 August 2013

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April 2022 Public Data File from Crossref

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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

WEBnm@: a web application for normal mode analyses of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Searching for new allosteric sites in enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Pathways of chaperone-mediated protein folding in the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Heat shock protein 90 as a molecular target for cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Heat-shock protein 90, a chaperone for folding and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Hsp90 as a capacitor of phenotypic variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Structure, function, and mechanism of the Hsp90 molecular chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Development and current status of the CHARMM force field for nucleic acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Hsp90: chaperoning signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Hsp90: a specialized but essential protein-folding tool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Modeling of loops in protein structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

Proteins with similar architecture exhibit similar large-scale dynamic behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

3 June 2018

The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Role of molecular chaperones in biogenesis of the protein kinome.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Localization of sites of interaction between p23 and Hsp90 in solution

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Gaussian Dynamics of Folded Proteins

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Anisotropic network model: systematic evaluation and a new web interface.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Network approach for capturing ligand-induced subtle global changes in protein structures

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Analysis of domain motions by approximate normal mode calculations.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071936

21 January 2018

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3747073

26 November 2018

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Creative elements: network-based predictions of active centres in proteins and cellular and social networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlating allostery with rigidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrete breathers in protein structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aha, another regulator for hsp90 chaperones

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the allosteric mechanism in pyrrolysyl-tRNA synthetase using energy-weighted network formalism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From a ratchet mechanism to random fluctuations evolution of Hsp90's mechanochemical cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23977182

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0071936

1 reference

Europe PubMed Central

2 November 2017

2013PLoSO...871936B

0 references

1 reference

Europe PubMed Central

2 November 2017

1 reference

Europe PubMed Central

2 November 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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