(Q30529898)

14 August 2017

Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex (English)

1 reference

14 August 2017

1 reference

1 reference

Robert P Carson

1

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author name string

Cary Fu

series ordinal

2

1 reference

14 August 2017

Peggy Winzenburger

series ordinal

3

1 reference

14 August 2017

Kevin C Ess

series ordinal

4

1 reference

14 August 2017

9 October 2012

1 reference

14 August 2017

Human Molecular Genetics

1 reference

14 August 2017

22

1 reference

14 August 2017

1

1 reference

14 August 2017

140-152

1 reference

describes a project that uses

14 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3522403/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.

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Sleep in attention-deficit/hyperactivity disorder in children and adults: past, present, and future

20 June 2018

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GABAergic interneuron development and function is modulated by the Tsc1 gene

20 June 2018

1 reference

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Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

20 June 2018

1 reference

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mTORC2 targets AGC kinases through Sin1-dependent recruitment

20 June 2018

1 reference

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A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

20 June 2018

1 reference

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Molecular substrates of action control in cortico-striatal circuits.

20 June 2018

1 reference

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Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

20 June 2018

1 reference

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Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

20 June 2018

1 reference

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mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Characterizing sleep disorders of adults with tuberous sclerosis complex: a questionnaire-based study and review

20 June 2018

1 reference

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Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities

20 June 2018

1 reference

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Sleep problems in the child with attention-deficit hyperactivity disorder: defining aetiology and appropriate treatments

20 June 2018

1 reference

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GSK-3β activity and hyperdopamine-dependent behaviors

20 June 2018

1 reference

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Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice

20 June 2018

1 reference

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Physiological regulation of Akt activity and stability.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Glutamatergic modulatory therapy for Tourette syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

mTOR complex 2 in adipose tissue negatively controls whole-body growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Akt/GSK3 signaling in the action of psychotropic drugs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

TOR regulation of AGC kinases in yeast and mammals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Tuberous sclerosis complex and epilepsy: recent developments and future challenges

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Parkin-deficient mice are not a robust model of parkinsonism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Managing epilepsy in tuberous sclerosis complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Upstream and downstream of mTOR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Akt activation by growth factors is a multiple-step process: the role of the PH domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Biophysical linkage between MRI and EEG amplitude in closed head injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Sleep disorders in tuberous sclerosis: a polysomnographic study.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Sleep disorder and epilepsy in children with tuberous sclerosis: a questionnaire-based study.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Brain lesions that produce delta waves in the EEG

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Spectral analysis of mouse EEG after the administration of N,N-dimethyltryptamine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522403

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

20 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Magnetic resonance imaging and diffusion-weighted imaging of normal-appearing white matter in children and young adults with tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Diffusion tensor imaging identifies changes in normal-appearing white matter within the epileptogenic zone in tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Diffusion tensor imaging of commissural and projection white matter in tuberous sclerosis complex and correlation with tuber load.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Genotype and psychological phenotype in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Psychiatric comorbid conditions in a clinic population of 241 patients with tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Home cage activity and activity-based measures of anxiety in 129P3/J, 129X1/SvJ and C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Wheel-running activity increases with social stress in male DBA mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Running wheel activity is sensitive to acute treatment with selective inhibitors for either serotonin or norepinephrine reuptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Digging and marble burying in mice: simple methods for in vivo identification of biological impacts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Animal models of obsessive-compulsive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Everolimus alters white matter diffusion in tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Hyperactivity and enhanced curiosity of mice expressing PKB/SGK-resistant glycogen synthase kinase-3 (GSK-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

Elevated zero maze: a paradigm to evaluate antianxiety effects of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS414

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS414

1 reference

release_7va5irdsdzd2jk7g757znf2td4

14 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7va5irdsdzd2jk7g757znf2td4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

14 August 2017

1 reference