(Q33604076)

28 July 2017

Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling (English)

1 reference

28 July 2017

A B Hanker

1

1 reference

28 July 2017

N Mitin

2

1 reference

28 July 2017

R S Wilder

3

1 reference

28 July 2017

E P Henske

4

1 reference

28 July 2017

F Tamanoi

5

1 reference

28 July 2017

A D Cox

6

1 reference

28 July 2017

C J Der

7

1 reference

28 July 2017

language of work or name

English

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publication date

19 October 2009

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28 July 2017

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28 July 2017

29

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28 July 2017

380-391

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28 July 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2009.336

28 July 2017

0 references

cites work

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

RalA functions as an indispensable signal mediator for the nutrient-sensing system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Tumorigenic activity and therapeutic inhibition of Rheb GTPase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The switch I region of Rheb is critical for its interaction with FKBP38.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Constitutively active Rheb induces oncogenic transformation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Inhibitors of chronically active ras: potential for treatment of human malignancies.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Ral GTPases and cancer: linchpin support of the tumorigenic platform

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Localization of Rheb to the endomembrane is critical for its signaling function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Rheb binds and regulates the mTOR kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Dysregulation of the TSC-mTOR pathway in human disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The Rheb family of GTP-binding proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Switch-of-Function Mutants Based on Morphology Classification of Ras Superfamily Small GTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Farnesyltransferase inhibitors: promises and realities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Dislodgment and accelerated degradation of Ras.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809798

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

Post-prenylation-processing enzymes as new targets in oncogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.336

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.336

1 reference

Dimensions Publication ID

28 July 2017

0 references

1 reference

28 July 2017

1 reference