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Constitutively active Rheb induces oncogenic transformation
scientific article published on 02 June 2008
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scholarly article
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Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
title
Constitutively active Rheb induces oncogenic transformation
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
author name string
H Jiang
series ordinal
1
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stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
P K Vogt
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2
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Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
language of work or name
English
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publication date
2 June 2008
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Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
published in
Oncogene
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stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
volume
27
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stated in
Europe PubMed Central
PMCID
2562864
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17 August 2017
issue
43
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Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
page(s)
5729-5740
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stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
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ImageJ
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2562864/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
exact match
https://scigraph.springernature.com/pub.10.1038/onc.2008.180
0 references
cites work
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Localization of Rheb to the endomembrane is critical for its signaling function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb binds and regulates the mTOR kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Retroviral oncogenes and TOR.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Drosophila Rheb GTPase is required for cell cycle progression and cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Rheb promotes cell growth as a component of the insulin/TOR signalling network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Binding of the corepressor TLE1 to Qin enhances Qin-mediated transformation of chicken embryo fibroblasts
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
29 September 2017
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
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PubMed Central
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29 September 2017
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
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PubMed Central
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29 September 2017
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
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29 September 2017
Cellular survival: a play in three Akts
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29 September 2017
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
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29 September 2017
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
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29 September 2017
The akt kinase: molecular determinants of oncogenicity
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29 September 2017
The DF-1 chicken fibroblast cell line: transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses
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29 September 2017
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
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29 September 2017
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
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29 September 2017
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
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29 September 2017
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
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29 September 2017
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
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29 September 2017
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.
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29 September 2017
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
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29 September 2017
Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
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29 September 2017
A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb
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29 September 2017
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein
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29 September 2017
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
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29 September 2017
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
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29 September 2017
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
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29 September 2017
Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors
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29 September 2017
Defectiveness of avian myelocytomatosis virus MC29: isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesis
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29 September 2017
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Characterization of Rheb functions using yeast and mammalian systems
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27 June 2018
Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.
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27 June 2018
Mechanisms and consequences of activation of protein kinase B/Akt
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27 June 2018
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27 June 2018
Characteristics of two new avian tumor virus subgroups
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27 June 2018
Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences
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27 June 2018
Phosphorylation by Akt disables the anti-oncogenic activity of YB-1.
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4 September 2018
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.
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Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast
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4 September 2018
Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway
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4 September 2018
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
1 reference
stated in
PubMed Central
reference URL
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retrieved
4 September 2018
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells
1 reference
stated in
PubMed Central
reference URL
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retrieved
4 September 2018
Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
Expression of a down-regulated target, SSeCKS, reverses v-Jun-induced transformation of 10T1/2 murine fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562864
retrieved
4 September 2018
Identifiers
DOI
10.1038/ONC.2008.180
1 reference
stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
Dimensions Publication ID
1043320506
0 references
PMCID
2562864
1 reference
stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
PubMed ID
18521078
1 reference
stated in
Europe PubMed Central
PMCID
2562864
retrieved
17 August 2017
ResearchGate publication ID
51397556
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