(Q33662415)

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Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors

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scholarly article

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Europe PubMed Central

28 July 2017

Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors (English)

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Europe PubMed Central

28 July 2017

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Yves Pommier

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Europe PubMed Central

28 July 2017

author name string

Peng-Cheng Lv

1

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Europe PubMed Central

28 July 2017

Keli Agama

2

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Europe PubMed Central

28 July 2017

Christophe Marchand

3

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Europe PubMed Central

28 July 2017

Mark Cushman

5

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Europe PubMed Central

28 July 2017

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publication date

6 May 2014

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Europe PubMed Central

28 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

28 July 2017

57

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Europe PubMed Central

28 July 2017

10

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Europe PubMed Central

28 July 2017

4324-4336

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Europe PubMed Central

28 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4033654/fullTextXML

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Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

1 reference

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TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

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Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)

1 reference

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Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I

1 reference

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5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

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21 June 2018

Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors

1 reference

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Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

1 reference

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Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships

1 reference

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Interfacial inhibitors: targeting macromolecular complexes

1 reference

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7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents

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1 reference

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4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors

1 reference

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21 June 2018

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

1 reference

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Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy

1 reference

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Next generation topoisomerase I inhibitors: Rationale and biomarker strategies

1 reference

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21 June 2018

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

1 reference

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21 June 2018

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization

1 reference

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21 June 2018

Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors

1 reference

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21 June 2018

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

1 reference

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21 June 2018

Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures

1 reference

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21 June 2018

Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles

1 reference

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Topoisomerase I inhibitors: camptothecins and beyond

1 reference

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21 June 2018

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

1 reference

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21 June 2018

Repair of topoisomerase I-mediated DNA damage

1 reference

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SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

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Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings

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The role of TDP1 from budding yeast in the repair of DNA damage

1 reference

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Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues

1 reference

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ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins

1 reference

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21 June 2018

Camptothecin: current perspectives

1 reference

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Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes

1 reference

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Topotecan dosing guidelines in ovarian cancer: reduction and management of hematologic toxicity

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Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen

1 reference

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Apoptosis induced by topoisomerase inhibitors

1 reference

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Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide

1 reference

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Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures

1 reference

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21 June 2018

The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

1 reference

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21 June 2018

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

1 reference

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Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.

1 reference

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Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

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Topoisomerase I poisons and suppressors as anticancer drugs

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Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

1 reference

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Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate

1 reference

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Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

1 reference

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21 June 2018

A model for the mechanism of human topoisomerase I

1 reference

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

1 reference

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beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin

1 reference

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21 June 2018

Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin

1 reference

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21 June 2018

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1 reference

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Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

1 reference

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21 June 2018

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1 reference

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21 June 2018

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

1 reference

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Mechanisms of camptothecin resistance by human topoisomerase I mutations

1 reference

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30 October 2018

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

1 reference

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Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

1 reference

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30 October 2018

Differential interactions of camptothecin lactone and carboxylate forms with human blood components.

1 reference

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Limited sampling model for area under the concentration time curve of total topotecan

1 reference

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Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/24800942

12 December 2020

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inferred from PubMed ID database lookup

Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/24800942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24800942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cytotoxicity of clinically important camptothecin derivatives in P-glycoprotein-overexpressing cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/24800942

12 December 2020

based on heuristic

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Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24800942

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM500294A

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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