(Q33701979)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Seung-Min Shin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Dong-Ki Choi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Keunok Jung

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jeomil Bae

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Ji-Sun Kim

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Seong-Wook Park

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Ki-Hoon Song

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

language of work or name

English

0 references

publication date

10 May 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

page(s)

15090

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

20 March 2020

copyright license

start time

10 May 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5436137/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms15090

0 references

cites work

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

1 reference

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Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening

21 June 2018

1 reference

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Antibodies to watch in 2016.

21 June 2018

1 reference

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Pharmacokinetic properties of IgG and various Fc fusion proteins in mice

21 June 2018

1 reference

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Quantitative assessment of cellular uptake and cytosolic access of antibody in living cells by an enhanced split GFP complementation assay

21 June 2018

1 reference

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Direct Modulation of Small GTPase Activity and Function

21 June 2018

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

21 June 2018

1 reference

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Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif.

21 June 2018

1 reference

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Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions

21 June 2018

1 reference

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Inhibition of Ras signaling by blocking Ras-effector interactions with cyclic peptides

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Drugging the undruggable RAS: Mission possible?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Delivery of antibodies to the cytosol: debunking the myths

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Dragging ras back in the ring

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Enhancement of the tumor penetration of monoclonal antibody by fusion of a neuropilin-targeting peptide improves the antitumor efficacy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Construction of a large synthetic human Fab antibody library on yeast cell surface by optimized yeast mating

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

The quest to overcome resistance to EGFR-targeted therapies in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Mutant and wild-type Ras: co-conspirators in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

A comprehensive survey of Ras mutations in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

RAS oncogenes: weaving a tumorigenic web

21 June 2018

1 reference

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A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth

21 June 2018

1 reference

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Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo

21 June 2018

1 reference

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Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells

21 June 2018

1 reference

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Integrins in cancer: biological implications and therapeutic opportunities

21 June 2018

1 reference

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Improved binding of raf to Ras.GDP is correlated with biological activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Ras oncogenes: split personalities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Comparing antibody and small-molecule therapies for cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Preparation of GTPases for structural and biophysical analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Oncolytic reovirus against ovarian and colon cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

The guanine nucleotide-binding switch in three dimensions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

A complete library of point substitution mutations in the glucocorticoid response element of mouse mammary tumor virus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape.

21 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

Analysis of Ras activation in living cells with GFP-RBD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin β1-driven Src-Akt bypass signaling.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436137

Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes

30 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

Metal-bis(2-picolyl)amine complexes as state 1(T) inhibitors of activated Ras protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

7 January 2021

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

7 January 2021

The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

7 January 2021

Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

7 January 2021

Structural and biochemical analysis of Ras-effector signaling via RalGDS

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS15090

7 January 2021

Isolation of Early and Late Endosomes by Density Gradient Centrifugation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28489072

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCOMMS15090

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 March 2020

ADS bibcode

2017NatCo...815090S

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28489072%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference