(Q34145575)

31 July 2017

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title

Inhibition of protein kinase B/Akt. implications for cancer therapy (English)

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31 July 2017

2

Brian A Hemmings

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31 July 2017

1

Michelle M Hill

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31 July 2017

publication date

1 February 2002

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Pharmacology & Therapeutics

31 July 2017

published in

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31 July 2017

volume

93

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31 July 2017

issue

2-3

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31 July 2017

page(s)

243-251

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Mechanism of activation of protein kinase B by insulin and IGF-1

31 July 2017

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7 January 2021

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

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7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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7 January 2021

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

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7 January 2021

Role of translocation in the activation and function of protein kinase B

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7 January 2021

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

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7 January 2021

Control of apoptosis by Rel/NF-kappaB transcription factors

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7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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7 January 2021

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

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7 January 2021

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

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7 January 2021

Oncogenic kinase signalling

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7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

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7 January 2021

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

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7 January 2021

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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7 January 2021

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

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7 January 2021

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

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7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

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7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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7 January 2021

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

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7 January 2021

Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase

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7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

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7 January 2021

Proliferation, cell cycle and apoptosis in cancer

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7 January 2021

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

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7 January 2021

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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7 January 2021

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

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7 January 2021

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

1 reference

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7 January 2021

Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002

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7 January 2021

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

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7 January 2021

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

1 reference

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7 January 2021

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

1 reference

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7 January 2021

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

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7 January 2021

Molecular cloning of a second form of rac protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

STI571: targeting BCR-ABL as therapy for CML.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Inhibition of cAMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Mammary gland involution is delayed by activated Akt in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Integrin-linked kinase (ILK): a "hot" therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Akt regulates cell survival and apoptosis at a postmitochondrial level

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900193-6

7 January 2021

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.

1 reference

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7 January 2021

10.1016/S0163-7258(02)00193-6

Identifiers

DOI

1 reference

31 July 2017

1 reference