(Q34156724)

31 July 2017

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title

Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence (English)

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31 July 2017

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Chin B Eap

1

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31 July 2017

Thierry Buclin

series ordinal

2

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31 July 2017

Pierre Baumann

series ordinal

3

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31 July 2017

1 January 2002

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Clinical Pharmacokinetics

31 July 2017

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31 July 2017

41

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31 July 2017

1153-1193

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31 July 2017

14

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https://scigraph.springernature.com/pub.10.2165/00003088-200241140-00003

31 July 2017

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cites work

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

1 reference

12 December 2020

Glucuronidation of 3'-azido-3'-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid

1 reference

12 December 2020

Disposition of methadone in methadone maintenance

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12 December 2020

Urinary metabolites of DL-methadone in maintenance subjects

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12 December 2020

Therapeutic drug monitoring of methadone in HIV-infected patients receiving protease inhibitors

1 reference

12 December 2020

Serum levels of methadone in maintenance clients who persist in illicit drug use

1 reference

12 December 2020

Changes in methadone treatment practices: results from a national panel study, 1988-2000.

1 reference

12 December 2020

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

1 reference

12 December 2020

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

1 reference

12 December 2020

Methadone dose increase and abstinence reinforcement for treatment of continued heroin use during methadone maintenance

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12 December 2020

Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.

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12 December 2020

Comment: opiate withdrawal symptoms induced by antiretroviral drugs

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12 December 2020

Postoperative pain control with methadone: influence of supplementary methadone doses and blood concentration--response relationships

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12 December 2020

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception

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12 December 2020

The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord.

1 reference

12 December 2020

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

1 reference

12 December 2020

Effects of liver disease on urinary excretion of methadone and metabolites in maintenance patients: quantitation by direct probe chemical ionization mass spectrometry

1 reference

12 December 2020

The use of plasma levels to optimize methadone maintenance treatment

1 reference

12 December 2020

Steady-state pharmacokinetics of methadone in opioid addicts

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12 December 2020

A MEDICAL TREATMENT FOR DIACETYLMORPHINE (HEROIN) ADDICTION. A CLINICAL TRIAL WITH METHADONE HYDROCHLORIDE.

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12 December 2020

The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac

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12 December 2020

Metabolic interactions between opiates and alcohol

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12 December 2020

Estimation of methadone clearance: application in the management of cancer pain

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12 December 2020

High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment

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12 December 2020

d-Methadone is antinociceptive in the rat formalin test

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12 December 2020

QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients

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12 December 2020

Diazepam and methadone blood levels following concurrent administration of diazepam and methadone.

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12 December 2020

Stereoselective determination of methadone in serum by HPLC following solid-phase extraction on disk

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12 December 2020

The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment

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12 December 2020

Pharmacologic treatment of heroin-dependent patients

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12 December 2020

Methadone maintenance treatment: is it possible to adapt the daily doses to the metabolic activity of the patient?

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12 December 2020

Drug binding to human alpha-1-acid glycoprotein in health and disease

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12 December 2020

Morphine and methadone binding to human serum proteins

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12 December 2020

Retention, HIV risk, and illicit drug use during treatment: methadone dose and visit frequency

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12 December 2020

Efavirenz decreases methadone blood concentrations

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12 December 2020

Hepatic extraction of long- and short-acting narcotics in the isolated perfused rabbit liver

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12 December 2020

The emerging role of cytochrome P450 3A in psychopharmacology

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12 December 2020

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

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12 December 2020

Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma

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12 December 2020

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

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12 December 2020

Prevalence and correlates of the injection of methadone syrup in Sydney, Australia

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12 December 2020

Utilization of plasma and urine methadone concentration measurements to limit narcotics use in methadone maintenance patients: II. Generation of plasma concentration response curves

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12 December 2020

Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment

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12 December 2020

Ten patients prescribed high dose methadone maintenance in general practice

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12 December 2020

Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts.

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12 December 2020

Methadone maintenance treatment: an update.

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12 December 2020

Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.

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12 December 2020

Optimizing long-term response to methadone maintenance treatment: a 152-week follow-up using higher-dose methadone.

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12 December 2020

Effects of dl-methadone on the response to physiological transmitters and on several functional parameters of the isolated guinea-pig heart

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12 December 2020

Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection

1 reference

12 December 2020

Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

1 reference

12 December 2020

A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence

1 reference

12 December 2020

Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment

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12 December 2020

The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz

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12 December 2020

Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain

1 reference

12 December 2020

Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts.

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12 December 2020

Influence of plasma-protein binding on analgesic effect of methadone in rats with spontaneous withdrawal

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12 December 2020

Changes in Methadone Treatment Practices: Results from a Panel Study, 1988–1995

1 reference

12 December 2020

Orosomucoid (alpha-1 acid glycoprotein) phenotyping by use of immobilized pH gradients with 8M urea and immunoblotting

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12 December 2020

Enantioselective high-performance liquid chromatography determination of methadone enantiomers and its major metabolite in human biological fluids using a new derivatized cyclodextrin-bonded phase

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12 December 2020

Altered methadone analgesia due to changes in plasma protein binding: Role of the route of administration

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12 December 2020

Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users.

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12 December 2020

Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers

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12 December 2020

Implications of methadone maintenance for theories of narcotic addiction

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12 December 2020

Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient

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12 December 2020

HIV transmission and the cost-effectiveness of methadone maintenance.

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12 December 2020

The levels of methadone in the plasma in methadone maintenance

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12 December 2020

Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users

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12 December 2020

Phenytoin-Induced Methadone Withdrawal

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12 December 2020

Methadone: a review of its pharmacokinetic/pharmacodynamic properties.

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12 December 2020

Methadone maintenance treatment in opiate dependence: a review.

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12 December 2020

Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome

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12 December 2020

Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone

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12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

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12 December 2020

Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert

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12 December 2020

Diazepam and methadone interactions in methadone maintenance.

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12 December 2020

Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein

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12 December 2020

Deaths of heroin addicts starting on a methadone maintenance programme

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12 December 2020

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

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12 December 2020

Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis

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12 December 2020

Inadequate plasma concentrations in some high-dose methadone maintenance patients

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12 December 2020

Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain

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12 December 2020

Stereoselective disposition of methadone in man.

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12 December 2020

The effect of tobacco smoking on subjective symptoms of inadequacy ("not holding") of methadone dose among opiate addicts in methadone maintenance treatment.

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12 December 2020

Cytochrome P4503A4 metabolic activity, methadone blood concentrations, and methadone doses

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12 December 2020

Methadone concentrations in plasma and their relationship to drug dosage

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12 December 2020

Plasma methadone measurements and their role in methadone detoxification programs

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12 December 2020

Population-based pharmacokinetic approach for methadone monitoring of opiate addicts: potential clinical utility

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12 December 2020

Effect of severe alcoholic liver disease on the disposition of methadone in maintenance patients

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12 December 2020

Clinical pharmacokinetics of methadone

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12 December 2020

Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein

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12 December 2020

Methadone withdrawal when starting an antiretroviral regimen including nevirapine

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12 December 2020

Methadone maintenance: Effect of urinary pH on renal clearance in chronic high and low doses

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12 December 2020

Prescribing injectable and oral methadone to opiate addicts: results from the 1995 national postal survey of community pharmacies in England and Wales

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12 December 2020

The use of serum methadone levels in patients receiving methadone maintenance.

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12 December 2020

Methadone binding to human plasma albumin

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12 December 2020

Out-patient compliance with antidepressant medication

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12 December 2020

Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.

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12 December 2020

Increase of Oral Methadone Dose in Methadone Injecting Patients

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12 December 2020

High-dose methadone and the need for drug measurements in plasma

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12 December 2020

Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components

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12 December 2020

Pharmacokinetics of methadone in methadone maintenance treatment: characterization of therapeutic failures

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12 December 2020

Disposition of methadone in man after a single oral dose

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12 December 2020

The genetic variant A of human alpha 1-acid glycoprotein limits the blood to brain transfer of drugs it binds.

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12 December 2020

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

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12 December 2020

Interaction between ethanol and opioids in a protozoan assay

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12 December 2020

Alpha 1-acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome.

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12 December 2020

Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride

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12 December 2020

Methadone, ciprofloxacin, and adverse drug reactions

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12 December 2020

The effect of sertraline on methadone plasma levels in methadone-maintenance patients

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12 December 2020

Pharmacokinetics of opioids in renal dysfunction

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12 December 2020

Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.

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12 December 2020

Methadone binding to human plasma proteins

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12 December 2020

Methadone-disulfiram interaction during methadone maintenance

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12 December 2020

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

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12 December 2020

Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method

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12 December 2020

A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence

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12 December 2020

A therapeutic use of the methadone fluvoxamine drug interaction

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12 December 2020

L-Methadone and D,L-methadone in methadone maintenance treatment: a comparison of therapeutic effectiveness and plasma concentrations

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12 December 2020

Very High Cytochrome P4501A2 Activity and Nonresponse to Clozapine

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12 December 2020

Methadone injecting in Australia: a tale of two cities

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12 December 2020

The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone

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12 December 2020

Quantitation of methadone enantiomers in humans using stable isotope-labeled [2H3]-, [2H5]-, and [2H8]Methadone

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12 December 2020

Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration-effect relationships

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12 December 2020

Opiate Receptor: Demonstration in Nervous Tissue

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12 December 2020

Phenytoin and Methadone Tolerance

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12 December 2020

A single dose of methadone inhibits cytochrome P-4503A activity in healthy volunteers as assessed by the urinary cortisol ratio

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12 December 2020

A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control

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12 December 2020

Stereospecific gas chromatographic method for determination of methadone in serum

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12 December 2020

Methadone blood concentrations are decreased by the administration of abacavir plus amprenavir

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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12 December 2020

Cocaine abuse sharply reduced in an effective methadone maintenance program

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12 December 2020

Stereoselective pharmacokinetics of methadone in chronic pain patients

1 reference

12 December 2020

Side effects of levomethadone and racemic methadone in a maintenance program

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12 December 2020

Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats.

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12 December 2020

Probable metabolic interaction between methadone and fluvoxamine in addict patients

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12 December 2020

Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two

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12 December 2020

Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse

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12 December 2020

Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord

1 reference

12 December 2020

Effect of fusidic acid on the hepatic cytochrome P450 enzyme system

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12 December 2020

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

1 reference

12 December 2020

Induction of antibodies to methadone during methadone maintenance treatment of heroin addicts and its possible clinical implications.

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12 December 2020

The addiction liability of some drugs of the methadon series.

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12 December 2020

Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases

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12 December 2020

Pharmacodynamics and Pharmacokinetics of Methadone during the Perioperative Period

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12 December 2020

Oral and intravenous methadone use: some clinical and pharmacokinetic aspects

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12 December 2020

The effect of diazepam on the metabolism of methadone by the liver of methadone-dependent rats.

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12 December 2020

Long QT syndromes and torsade de pointes

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12 December 2020

The effect of fluconazole on the clinical pharmacokinetics of methadone

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12 December 2020

The relationship between mood state and plasma methadone concentration in maintenance patients.

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12 December 2020

Variations in methadone treatment practices. Results from a national study

1 reference

12 December 2020

High Interindividual Variability of Methadone Enantiomer Blood Levels to Dose Ratios

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12 December 2020

Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program

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12 December 2020

[Frequency of injection of oral methadone solutions at treatment center for opiate dependence]

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12 December 2020

Torsade de pointes associated with very-high-dose methadone

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12 December 2020

Ultrafiltration using the Amicon MPS-1 for assessing methadone plasma protein binding

1 reference

12 December 2020

Optimizing response to methadone maintenance treatment: use of higher-dose methadone

1 reference

12 December 2020

A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer

1 reference

12 December 2020

Fluoxetine Addition to Methadone in Addicts: Pharmacokinetic Aspects

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12 December 2020

Drug interactions with antiviral drugs

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12 December 2020

Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

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12 December 2020

Use of transgenic mice for the characterization of human alpha 1-acid glycoprotein (orosomucoid) variants

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12 December 2020

The pharmacokinetics of methadone in healthy subjects and opiate users

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12 December 2020

Interaction of methadone and ethanol metabolism.

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12 December 2020

Rehabilitation of heroin addicts after blockade with methadone

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12 December 2020

Methadone withdrawal symptoms with nevirapine and efavirenz

1 reference

12 December 2020

Effects of liver disease on fecal excretion of methadone and its unconjugated metabolites in maintenance patients. Quantitation by direct probe chemical ionization mass spectrometry

1 reference

12 December 2020

Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations

1 reference

12 December 2020

Chiral analysis of methadone in plasma by high-performance liquid chromatography

1 reference

12 December 2020

The efficacy of L-methadone and racemic methadone in substitution treatment for opiate addicts--a double-blind comparison

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12 December 2020

Effect of urinary pH on the disposition of methadone in man

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12 December 2020

Clinical effects and pharmacokinetics of racemic methadone and its optical isomers

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12 December 2020

Measuring compliance in methadone maintenance patients: use of a pharmacologic indicator to "estimate" methadone plasma levels.

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12 December 2020

Altered methadone pharmacokinetics in methadone-maintained pregnant women

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12 December 2020

Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.

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12 December 2020

Increase in desipramine serum levels associated with methadone treatment.

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12 December 2020

Interactions between methadone and medications used to treat HIV infection: a review

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12 December 2020

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

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12 December 2020

Methadone dosage and retention of patients in maintenance treatment.

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12 December 2020

Influence of concomitant drugs on methadone elimination half-life in patients under a maintenance treatment

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12 December 2020

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

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12 December 2020

When "enough" is not enough: new perspectives on optimal methadone maintenance dose.

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12 December 2020

Rated well-being in relation to plasma concentrations of l- and d-methadone in satisfied and dissatisfied patients on methadone maintenance treatment

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12 December 2020

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells.

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12 December 2020

Methadone maintenance: Plasma levels and therapeutic outcome

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12 December 2020

Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users

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12 December 2020

Expression of CYP1A1 and CYP1A2 genes in human liver

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12 December 2020

Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial

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12 December 2020

Psychophysiological reactions in methadone maintenance patients do not correlate with methadone plasma levels.

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12 December 2020

Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

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12 December 2020

Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4

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12 December 2020

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone

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12 December 2020

Grapefruit juice-drug interactions

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12 December 2020

Codeine o-demethylation: Rat strain differences and the effects of inhibitors

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12 December 2020

Decreased methadone effect after ritonavir initiation

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12 December 2020

Pharmacologic comparison of the optical isomers of methadon.

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12 December 2020

Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction.

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12 December 2020

Fluoxetine for cocaine dependence in methadone maintenance: quantitative plasma and urine cocaine/benzoylecgonine concentrations

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12 December 2020

Methadone is poorly removed by haemodialysis

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12 December 2020

Ultrarapid metabolism of clomipramine in a therapy-resistant depressive patient, as confirmed by CYP2 D6 genotyping.

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12 December 2020

Fluvoxamine-methadone interaction.

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12 December 2020

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans

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12 December 2020

Methadone use in patients with chronic renal disease

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12 December 2020

Methadone disposition in patients with chronic liver disease

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12 December 2020

Methadone plasma protein binding: alterations in cancer and displacement from alpha 1-acid glycoprotein

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12 December 2020

Therapeutic drug monitoring for methadone: scanning the horizon.

1 reference

12 December 2020

Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes

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12 December 2020

Biochemical and molecular basis of alcohol-induced injury to liver and other tissues

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12 December 2020

Pharmacokinetics of methadone during maintenance treatment: adaptive changes during the induction phase

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12 December 2020

In vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine

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12 December 2020

Three oral formulations of methadone. A clinical and pharmacodynamic comparison

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12 December 2020

Effect of ritonavir/saquinavir on stereoselective pharmacokinetics of methadone: results of AIDS Clinical Trials Group (ACTG) 401.

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12 December 2020

Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate.

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12 December 2020

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

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12 December 2020

10.2165/00003088-200241140-00003

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

0 references

1 reference