(Q34330816)

1 August 2017

title

Phi-value analysis and the nature of protein-folding transition states (English)

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1 August 2017

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1

Alan R Fersht

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1 August 2017

Satoshi Sato

2

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1 August 2017

language of work or name

English

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publication date

18 May 2004

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

101

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1 August 2017

issue

21

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1 August 2017

page(s)

7976-7981

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Theory of protein folding

1 August 2017

cites work

1 reference

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Testing protein-folding simulations by experiment: B domain of protein A.

6 July 2018

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Cooperativity in two-state protein folding kinetics.

6 July 2018

1 reference

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Origin of unusual phi-values in protein folding: evidence against specific nucleation sites

6 July 2018

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Unifying features in protein-folding mechanisms

6 July 2018

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The present view of the mechanism of protein folding

6 July 2018

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The complete folding pathway of a protein from nanoseconds to microseconds

6 July 2018

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Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins

6 July 2018

1 reference

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Is there a unifying mechanism for protein folding?

6 July 2018

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Evidence for sequential barriers and obligatory intermediates in apparent two-state protein folding

6 July 2018

1 reference

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Determination of a transition state at atomic resolution from protein engineering data

6 July 2018

1 reference

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Protein folding kinetics beyond the phi value: using multiple amino acid substitutions to investigate the structure of the SH3 domain folding transition state

6 July 2018

1 reference

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Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.

6 July 2018

1 reference

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Stiffness of the distal loop restricts the structural heterogeneity of the transition state ensemble in SH3 domains

6 July 2018

1 reference

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Protein folding and unfolding at atomic resolution

6 July 2018

1 reference

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Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations

6 July 2018

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Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism

6 July 2018

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Experiment and theory highlight role of native state topology in SH3 folding

6 July 2018

1 reference

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The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved.

6 July 2018

1 reference

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Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding.

6 July 2018

1 reference

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Nucleation mechanisms in protein folding

6 July 2018

1 reference

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Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein folding

6 July 2018

1 reference

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Single versus parallel pathways of protein folding and fractional formation of structure in the transition state

6 July 2018

1 reference

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Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.

6 July 2018

1 reference

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Characterizing transition states in protein folding: an essential step in the puzzle

6 July 2018

1 reference

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Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2.

6 July 2018

1 reference

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Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Hydrogen bonding and biological specificity analysed by protein engineering

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Mapping the transition state and pathway of protein folding by protein engineering

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Energetics of complementary side-chain packing in a protein hydrophobic core

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Transient folding intermediates characterized by protein engineering

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

The folding of an enzyme. IV. Structure of an intermediate in the refolding of barnase analysed by a protein engineering procedure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

The folding of an enzyme. III. Structure of the transition state for unfolding of barnase analysed by a protein engineering procedure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

The folding of an enzyme. II. Substructure of barnase and the contribution of different interactions to protein stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

Parameters for the Description of Transition States

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

Commitment and nucleation in the protein G transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

Hammond behavior versus ground state effects in protein folding: evidence for narrow free energy barriers and residual structure in unfolded states

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

Complete change of the protein folding transition state upon circular permutation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419542

Movement of the position of the transition state in protein folding

27 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

Affinities of amino acid side chains for solvent water

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

The formation of a native-like structure containing eight conserved hydrophobic residues is rate limiting in two-state protein folding of ACBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402684101

Alpha-helix stability in proteins. I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at solvent-exposed surfaces

21 January 2018

1 reference

12 December 2020

Folding pathway enigma

1 reference

12 December 2020

Relationships between apparent binding energies measured in site-directed mutagenesis experiments and energetics of binding and catalysis

1 reference

12 December 2020

Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfo

1 reference

12 December 2020

Structure of the hydrophobic core in the transition state for folding of chymotrypsin inhibitor 2: a critical test of the protein engineering method of analysis

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0402684101

1 reference

1 August 2017

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1 August 2017

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