(Q34333456)

8 January 2018

title

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system (English)

1 reference

8 January 2018

Erratum: Corrigendum: ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

corrigendum / erratum

1 reference

10.1038/NCHEMBIO0613-406D

DOI

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NCHEMBIO0613-406D

author

Paul A Clarke

3

1 reference

8 January 2018

Laurence Pearl

6

1 reference

8 January 2018

Rahul S Samant

object named as

Rahul S Samant

2

0 references

Paul Workman

4

object named as

Paul Workman

1 reference

8 January 2018

Sigrun Polier

1

1 reference

8 January 2018

publication date

17 March 2013

1 reference

8 January 2018

published in

Nature Chemical Biology

1 reference

8 January 2018

volume

9

1 reference

8 January 2018

issue

5

1 reference

8 January 2018

page(s)

307-312

1 reference

8 January 2018

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

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1 reference

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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

6 July 2018

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Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

6 July 2018

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Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

6 July 2018

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The role of Hsp90 in protein complex assembly

6 July 2018

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

6 July 2018

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

6 July 2018

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

6 July 2018

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Protein kinase inhibitors: contributions from structure to clinical compounds

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

The Hsp90 molecular chaperone: an open and shut case for treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Inhibitors of the heat shock response: biology and pharmacology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Molecular chaperones and protein kinase quality control.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Structure of an Hsp90-Cdc37-Cdk4 complex.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Structure and mechanism of the Hsp90 molecular chaperone machinery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Insights into nucleotide binding in protein kinase A using fluorescent adenosine derivatives

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

Active and inactive protein kinases: structural basis for regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695660

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

Cdc37: a protein kinase chaperone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

A client-binding site of Cdc37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1212

21 January 2018

Identifiers

DOI

10.1038/NCHEMBIO.1212

1 reference

8 January 2018

PMC publication ID

5695660

1 reference

8 January 2018

PubMed publication ID

23502424

1 reference

8 January 2018