(Q34539886)

2 August 2017

1 reference

title

Genome editing in cardiovascular diseases (English)

1 reference

2 August 2017

cardiovascular disease

1 reference

Alanna Strong

1

1 reference

PubMed ID

27609628

2 August 2017

Kiran Musunuru

series ordinal

2

1 reference

PubMed ID

27609628

2 August 2017

language of work or name

English

0 references

publication date

9 September 2016

1 reference

Nature Reviews Cardiology

2 August 2017

1 reference

2 August 2017

14

1 reference

2 August 2017

1

1 reference

2 August 2017

11-20

1 reference

Genome editing with engineered zinc finger nucleases

2 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

TAL effectors: customizable proteins for DNA targeting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Development and applications of CRISPR-Cas9 for genome engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

FokI dimerization is required for DNA cleavage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A simple cipher governs DNA recognition by TAL effectors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Breaking the code of DNA binding specificity of TAL-type III effectors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Targeting DNA double-strand breaks with TAL effector nucleases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Multiplex genome engineering using CRISPR/Cas systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

RNA-guided human genome engineering via Cas9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Efficient genome editing in zebrafish using a CRISPR-Cas system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

In vivo genome editing using Staphylococcus aureus Cas9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Structure and Engineering of Francisella novicida Cas9.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Molecular views of recombination proteins and their control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Regulation of DNA repair throughout the cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Stimulation of homologous recombination through targeted cleavage by chimeric nucleases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A TALEN genome-editing system for generating human stem cell-based disease models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Genetic compensation induced by deleterious mutations but not gene knockdowns.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Multiple genome modifications by the CRISPR/Cas9 system in zebrafish.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Efficient Multiple Genome Modifications Induced by the crRNAs, tracrRNA and Cas9 Protein Complex in Zebrafish

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Gene targeting in the rat: advances and opportunities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Creation and characterization of a renin knockout rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Effective gene targeting in rabbits using RNA-guided Cas9 nucleases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Efficient creation of an APOE knockout rabbit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Targeted genomic integration of a selectable floxed dual fluorescence reporter in human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Bioluminescent imaging of genetically selected induced pluripotent stem cell-derived cardiomyocytes after transplantation into infarcted heart of syngeneic recipients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo-Brief Report

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Safety and efficacy of RNAi therapy for transthyretin amyloidosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

DNA targeting specificity of RNA-guided Cas9 nucleases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Nucleosomes Inhibit Cas9 Endonuclease Activity in Vitro.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Dynamics of CRISPR-Cas9 genome interrogation in living cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Small molecules enhance CRISPR genome editing in pluripotent stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A mechanism for the suppression of homologous recombination in G1 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Conformational control of DNA target cleavage by CRISPR-Cas9.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Rationally engineered Cas9 nucleases with improved specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2016.139

Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27609628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRCARDIO.2016.139

1 reference

2 August 2017

1 reference

PubMed ID

27609628