(Q34559507)

3 August 2017

title

Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins (English)

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3 August 2017

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5

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3 August 2017

6

Rajarshi Guha

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3 August 2017

Lavona Casson

1

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3 August 2017

Lauren Howell

2

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3 August 2017

Lesley A Mathews

3

1 reference

3 August 2017

Marc Ferrer

4

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3 August 2017

Jonathan M Keller

7

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3 August 2017

Craig Thomas

8

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3 August 2017

Leah J Siskind

9

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3 August 2017

Levi J Beverly

10

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3 August 2017

language of work or name

English

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publication date

16 January 2013

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3 August 2017

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3 August 2017

volume

8

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3 August 2017

issue

1

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3 August 2017

page(s)

e54525

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Creative Commons CC0 License

3 August 2017

copyright license

start time

16 January 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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7 July 2018

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Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

7 July 2018

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Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloid leukemia cells

7 July 2018

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Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells

7 July 2018

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7 July 2018

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Glucosylceramide in Humans

7 July 2018

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The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

7 July 2018

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Regulation of ceramide channels by Bcl-2 family proteins

7 July 2018

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Ceramide channels and their role in mitochondria-mediated apoptosis

7 July 2018

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7 July 2018

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

7 July 2018

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Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells

7 July 2018

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Principles of bioactive lipid signalling: lessons from sphingolipids

7 July 2018

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Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels

7 July 2018

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7 July 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

7 July 2018

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Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

7 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

7 July 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

7 July 2018

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Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

7 July 2018

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Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

7 July 2018

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Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Sphingosine kinase: biochemical and cellular regulation and role in disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

The Bcl-2 family: roles in cell survival and oncogenesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

7 July 2018

The Hallmarks of Cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

The Bcl-2 protein family: arbiters of cell survival

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Bax-dependent apoptosis induced by ceramide in HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0054525

Genetic control of programmed cell death in the nematode Caenorhabditis elegans.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546986

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

27 October 2018

1 reference

12 December 2020

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis

1 reference

12 December 2020

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

1 reference

12 December 2020

Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0054525

Identifiers

DOI

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3 August 2017

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3 August 2017

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