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Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.
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Europe PubMed Central
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3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
title
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
main subject
pathogenesis
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leukemia
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based on heuristic
inferred from title
author
Omar Abdel-Wahab
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1
1 reference
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Europe PubMed Central
PMCID
3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
author name string
Ross L Levine
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2
1 reference
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Europe PubMed Central
PMCID
3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
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English
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1 May 2013
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Europe PubMed Central
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3643757
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29 February 2020
published in
Blood
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Europe PubMed Central
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3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
volume
121
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Europe PubMed Central
PMCID
3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
page(s)
3563-3572
1 reference
stated in
Europe PubMed Central
PMCID
3643757
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
issue
18
1 reference
stated in
Europe PubMed Central
PMCID
3643757
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
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29 February 2020
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Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
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ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
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7 July 2018
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7 July 2018
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
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7 July 2018
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
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7 July 2018
IDH1 and IDH2 mutations in pediatric acute leukemia
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7 July 2018
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
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7 July 2018
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
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7 July 2018
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
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7 July 2018
TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study
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7 July 2018
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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7 July 2018
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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7 July 2018
DNMT3A Mutations in Acute Myeloid Leukemia
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7 July 2018
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
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7 July 2018
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
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7 July 2018
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
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7 July 2018
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
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7 July 2018
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
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7 July 2018
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2
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7 July 2018
Array-based genomic resequencing of human leukemia
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7 July 2018
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
1 reference
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7 July 2018
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
1 reference
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PubMed Central
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7 July 2018
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
1 reference
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PubMed Central
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7 July 2018
Identification of cell-active lysine specific demethylase 1-selective inhibitors
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7 July 2018
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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7 July 2018
ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1
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7 July 2018
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
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PubMed Central
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7 July 2018
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
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PubMed Central
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7 July 2018
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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7 July 2018
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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7 July 2018
Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.
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7 July 2018
MLL translocations, histone modifications and leukaemia stem-cell development
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7 July 2018
Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
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PubMed Central
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7 July 2018
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).
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7 July 2018
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.
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PubMed Central
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26 October 2018
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
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26 October 2018
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643757
retrieved
26 October 2018
Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23640996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23640996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23640996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23640996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23640996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutant DNMT3A: teaming up to transform
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23640996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1182/BLOOD-2013-01-451781
1 reference
stated in
Europe PubMed Central
PMCID
3643757
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PMCID
3643757
1 reference
stated in
Europe PubMed Central
PMCID
3643757
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PubMed ID
23640996
1 reference
stated in
Europe PubMed Central
PMCID
3643757
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23640996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
ResearchGate publication ID
236615019
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