(Q34661033)

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DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies

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Europe PubMed Central

PubMed publication ID

3 August 2017

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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based on heuristic

inferred from title

acute myeloid leukemia

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5

object named as

A Tefferi

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

A P Im

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

A R Sehgal

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

M P Carroll

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

B D Smith

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

D E Johnson

6

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Europe PubMed Central

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3 August 2017

M Boyiadzis

7

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Europe PubMed Central

PubMed publication ID

3 August 2017

publication date

4 April 2014

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

28

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Europe PubMed Central

PubMed publication ID

3 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1774-1783

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.

1 reference

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FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?

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Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents

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7 July 2018

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

1 reference

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7 July 2018

Origins of aberrant DNA methylation in acute myeloid leukemia

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7 July 2018

Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia

1 reference

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7 July 2018

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

1 reference

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7 July 2018

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.

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7 July 2018

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

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5-hydroxymethylcytosine and its potential roles in development and cancer.

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7 July 2018

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).

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7 July 2018

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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7 July 2018

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

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7 July 2018

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

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7 July 2018

Cancer statistics, 2013

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7 July 2018

Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia

1 reference

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7 July 2018

IDH mutations in acute myeloid leukemia

1 reference

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7 July 2018

Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics

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7 July 2018

Rare mutations in DNMT3A in myeloproliferative neoplasms and myelodysplastic syndromes.

1 reference

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7 July 2018

DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia

1 reference

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7 July 2018

Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia

1 reference

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7 July 2018

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia

1 reference

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7 July 2018

Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report

1 reference

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7 July 2018

Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia

1 reference

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7 July 2018

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

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7 July 2018

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

IDH mutation impairs histone demethylation and results in a block to cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia

1 reference

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7 July 2018

Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

Dnmt3a is essential for hematopoietic stem cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007.

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Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients

1 reference

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Prognostic significance of alterations in IDH enzyme isoforms in patients with AML treated with high-dose cytarabine and idarubicin

1 reference

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Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome

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Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

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IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F

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7 July 2018

Rare occurrence of DNMT3A mutations in myelodysplastic syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4234093

7 July 2018

CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors

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Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

1 reference

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7 July 2018

Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia

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7 July 2018

IDH1 and IDH2 mutations in pediatric acute leukemia

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7 July 2018

DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms

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7 July 2018

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

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7 July 2018

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

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Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications

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Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia: myths, controversies, and unknowns

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DNMT3A Mutations in Acute Myeloid Leukemia

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IDH mutations in glioma and acute myeloid leukemia

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7 July 2018

Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

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7 July 2018

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

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7 July 2018

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

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7 July 2018

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

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7 July 2018

WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations

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7 July 2018

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

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7 July 2018

Array-based genomic resequencing of human leukemia

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7 July 2018

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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7 July 2018

Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

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7 July 2018

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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7 July 2018

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

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7 July 2018

Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia

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7 July 2018

Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia

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7 July 2018

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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7 July 2018

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

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7 July 2018

Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase

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7 July 2018

Recurring mutations found by sequencing an acute myeloid leukemia genome

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7 July 2018

IDH1 and IDH2 mutations in gliomas

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7 July 2018

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

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7 July 2018

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

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7 July 2018

Epigenetics in cancer

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7 July 2018

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

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7 July 2018

Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study

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7 July 2018

Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B

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7 July 2018

GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations

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21 January 2018

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.

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21 January 2018

DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.

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21 January 2018

Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia.

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21 January 2018

Landmark analysis of DNMT3A mutations in hematological malignancies

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21 January 2018

Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia

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21 January 2018

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

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21 January 2018

IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia

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21 January 2018

Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response

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https://api.crossref.org/works/10.1038%2FLEU.2014.124

21 January 2018

A novel hierarchical prognostic model of AML solely based on molecular mutations

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21 January 2018

Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.124

21 January 2018

Taxing sugar-sweetened beverages

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.124

21 January 2018

IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.124

21 January 2018

Mutations and prognosis in primary myelofibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.124

21 January 2018

Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNMT3A mutations in myeloproliferative neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDH1 and IDH2 mutations in therapy-related myelodysplastic syndrome and acute myeloid leukemia are associated with a normal karyotype and with der(1;7)(q10;p10)

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24699305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2014.124

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

0 references

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