(Q34675038)

3 August 2017

Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons (English)

1 reference

3 August 2017

Min-Juan Wang

1

1 reference

3 August 2017

Yan-Chun Li

2

1 reference

3 August 2017

Melissa A Snyder

3

1 reference

3 August 2017

Huaixing Wang

4

1 reference

3 August 2017

Feng Li

5

1 reference

3 August 2017

Wen-Jun Gao

6

1 reference

3 August 2017

language of work or name

English

0 references

publication date

12 April 2013

1 reference

3 August 2017

1 reference

3 August 2017

8

1 reference

3 August 2017

4

1 reference

3 August 2017

e61787

1 reference

Creative Commons Attribution 4.0 International

3 August 2017

start time

12 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3625159/fullTextXML

inferred from PubMed Central ID database lookup

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Acute administration of typical and atypical antipsychotics reduces EEG γ power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in γ power

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mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum

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Routes, destinations and delays: recent advances in AMPA receptor trafficking

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Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.

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Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt/GSK-3β pathway in adult rat prefrontal cortex

7 July 2018

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Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus

7 July 2018

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LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia

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Evidence for abnormal forward trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia

7 July 2018

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Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons

7 July 2018

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Ras and Rap signaling in synaptic plasticity and mental disorders

7 July 2018

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Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats

7 July 2018

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Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex

7 July 2018

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Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia

7 July 2018

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7 July 2018

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Synaptic AMPA receptor plasticity and behavior.

7 July 2018

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

7 July 2018

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7 July 2018

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

7 July 2018

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The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

7 July 2018

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The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia.

7 July 2018

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Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

7 July 2018

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Schizophrenia: moving beyond monoamine antagonists

7 July 2018

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The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268.

7 July 2018

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The possible involvement of metabotropic glutamate receptors in schizophrenia

7 July 2018

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Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia.

7 July 2018

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Dopamine hypothesis of schizophrenia: making sense of it all.

7 July 2018

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

7 July 2018

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Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia

7 July 2018

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A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis

7 July 2018

1 reference

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Metabotropic glutamate receptors as drug targets

7 July 2018

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Regulatory mechanisms of AMPA receptors in synaptic plasticity

7 July 2018

1 reference

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Are compounds acting at metabotropic glutamate receptors the answer to treating depression?

7 July 2018

1 reference

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AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

7 July 2018

1 reference

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Recent advances in positive allosteric modulators of metabotropic glutamate receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).

7 July 2018

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Effects of the mGluR2/3 agonist LY354740 on computerized tasks of attention and working memory in marmoset monkeys

7 July 2018

1 reference

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

7 July 2018

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Activation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia

7 July 2018

1 reference

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Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia

7 July 2018

1 reference

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Bringing order to the glutamate chaos in schizophrenia

7 July 2018

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AMPA Receptor Trafficking at Excitatory Synapses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica multidrug resistance phenotype

7 July 2018

1 reference

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AMPA receptor trafficking and synaptic plasticity

7 July 2018

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Receptor trafficking and the plasticity of excitatory synapses.

7 July 2018

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Long-term depression induced by postsynaptic group II metabotropic glutamate receptors linked to phospholipase C and intracellular calcium rises in rat prefrontal cortex.

7 July 2018

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Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

7 July 2018

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Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

7 July 2018

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Postsynaptic organization and regulation of excitatory synapses

7 July 2018

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Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons

7 July 2018

1 reference

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Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

7 July 2018

1 reference

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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

7 July 2018

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Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus

7 July 2018

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Neurotransmitter aberrations in schizophrenia: new perspectives and therapeutic implications

7 July 2018

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Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus

7 July 2018

1 reference

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Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus.

7 July 2018

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The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations

7 July 2018

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Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

7 July 2018

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The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity

7 July 2018

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mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics

21 January 2018

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Immunoautoradiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia.

21 January 2018

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Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.

21 January 2018

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Immunocytochemistry and quantification of protein colocalization in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0061787

The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex

21 January 2018

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Repeated cocaine administration impairs group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex.

21 January 2018

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ERKs regulate PKC-dependent synaptic depression and declustering of glutamate receptors in cerebellar Purkinje cells

21 January 2018

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Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent.

21 January 2018

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Dopamine D(1) receptor-mediated enhancement of NMDA receptor trafficking requires rapid PKC-dependent synaptic insertion in the prefrontal neurons

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625159

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

26 October 2018

1 reference

12 December 2020

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

1 reference

12 December 2020

Treatment of schizophrenia and spectrum disorders: pharmacotherapy, psychosocial treatments, and neurotransmitter interactions

1 reference

12 December 2020

Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0061787

Identifiers

DOI

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference