(Q34685048)

3 August 2017

title

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation (English)

1 reference

3 August 2017

Weihong Song

11

0 references

Yigang Tong

Yigang Tong

6

0 references

Hinrich Gronemeyer

Hinrich Gronemeyer

9

0 references

Yili Wu

Yili Wu

2

0 references

Richard Flavell

10

Richard A Flavell

1 reference

3 August 2017

Xiulian Sun

1

1 reference

3 August 2017

Bin Chen

3

1 reference

3 August 2017

Zhuohua Zhang

4

1 reference

3 August 2017

Weihui Zhou

5

1 reference

3 August 2017

Junying Yuan

7

1 reference

3 August 2017

Kun Xia

8

1 reference

3 August 2017

language of work or name

English

0 references

publication date

7 January 2011

1 reference

Journal of Biological Chemistry

3 August 2017

published in

1 reference

3 August 2017

volume

286

1 reference

3 August 2017

issue

11

1 reference

3 August 2017

page(s)

9049-9062

1 reference

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

3 August 2017

cites work

1 reference

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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

7 July 2018

1 reference

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Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point

7 July 2018

1 reference

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NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.

7 July 2018

1 reference

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

7 July 2018

1 reference

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BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

7 July 2018

1 reference

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

7 July 2018

1 reference

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Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

KiSS-1/G protein-coupled receptor 54 metastasis suppressor pathway increases myocyte-enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Pathways towards and away from Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Caspase activation: revisiting the induced proximity model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Cytochrome C-mediated apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Increased apoptotic cell death in sporadic and genetic Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Therapeutic implications of HPA axis abnormalities in Alzheimer's disease: review and update.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Diversity in the mechanisms of neuronal cell death.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Mongolism; a chromosomal disease (trisomy).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Apoptosis and caspases in neurodegenerative diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

The role of modulatory calcineurin-interacting proteins in calcineurin signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Multiple domains of MCIP1 contribute to inhibition of calcineurin activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Mechanisms of caspase activation and inhibition during apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Too much of a good thing: mechanisms of gene action in Down syndrome.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

High level calcineurin activity predisposes neuronal cells to apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

7 July 2018

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Steroid hormones and their receptors in the brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Glucocorticoid interactions with memory function in schizophrenia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Controversies surrounding glucocorticoid-mediated cell death in the hippocampus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Changes of p53 in the brains of patients with Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Fas antigen expression in brains of patients with Alzheimer-type dementia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Ligand and subfield specificity of corticoid-induced neuronal loss in the rat hippocampal formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Decreased memory performance in healthy humans induced by stress-level cortisol treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Aggregate formation and synaptic abnormality induced by DSCR1.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059004

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

26 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177519

The somatic chromosomes in mongolism

21 January 2018

1 reference

12 December 2020

Down syndrome protein deters cancer: scientists reveal molecular mechanism

1 reference

12 December 2020

DSCR1 (ADAPT78) lethality: evidence for a protective effect of trisomy 21 genes?

1 reference

12 December 2020

Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles

1 reference

12 December 2020

Analysis of gene expression patterns during glucocorticoid-induced apoptosis using oligonucleotide arrays

1 reference

12 December 2020

Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.177519

1 reference

3 August 2017

1 reference

3 August 2017

1 reference