(Q34700113)

4 August 2017

Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb (English)

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4 August 2017

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1 reference

Peter Beemiller

4

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Joel A Swanson

object named as

Joel Swanson

6

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author name string

Yong Li

1

1 reference

4 August 2017

Yian Wang

2

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4 August 2017

Eunjung Kim

3

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4 August 2017

Cun-Yu Wang

5

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4 August 2017

Ming You

7

1 reference

4 August 2017

Kun-Liang Guan

8

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4 August 2017

language of work or name

English

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publication date

10 October 2007

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Journal of Biological Chemistry

4 August 2017

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4 August 2017

282

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4 August 2017

35803-35813

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4 August 2017

49

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Upstream and downstream of mTOR

4 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Signaling by target of rapamycin proteins in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Complexity of the TOR signaling network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Tuberous sclerosis: from tubers to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

The Rheb family of GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Regulation of the small GTPase Rheb by amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

BNip3 and signal-specific programmed death in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Bcl-2/adenovirus E1B 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung, liver, and bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Prenylated Rab acceptor protein is a receptor for prenylated small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

The carboxy terminal C-tail of BNip3 is crucial in induction of mitochondrial permeability transition in isolated mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Fluorescence resonance energy transfer-based stoichiometry in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

Reevaluation of the PPAR-β/δ Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705231200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705231200

1 reference

4 August 2017

1 reference