(Q34707865)

4 August 2017

1 reference

title

Pten signaling in gliomas. (English)

1 reference

4 August 2017

3

Guido Reifenberger

1 reference

4 August 2017

Christiane B Knobbe

1

1 reference

4 August 2017

Adrian Merlo

series ordinal

2

1 reference

4 August 2017

publication date

1 July 2002

1 reference

4 August 2017

1 reference

4 August 2017

volume

4

1 reference

4 August 2017

issue

3

1 reference

4 August 2017

page(s)

196-211

1 reference

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Identification of PTEN-related sequences in glioma cells and in non-neoplastic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

A highly conserved processed PTEN pseudogene is located on chromosome band 9p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The multiple roles of PTEN in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN mutations in gliomas and glioneuronal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

p27Kip1 expression by contact inhibition as a prognostic index of human glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Glioblastomas with an oligodendroglial component: a pathological and molecular study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Wortmannin sensitizes human glioblastoma cell lines carrying mutant and wild type TP53 gene to radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PIK3CA as an oncogene in cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN and myotubularin: novel phosphoinositide phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Microsatellite instability, PTEN and p53 germline mutations in glioma families

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

p27/kip1 expression in human astrocytic gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Genetic profile of gliosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN: life as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Regulation of PTEN transcription by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Investigation of germline PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 alterations in familial glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Molecular genetics of radiographically defined de novo glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

p53 and PTEN gene mutations in gemistocytic astrocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN controls tumor-induced angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2F4.3.196

21 January 2018

Identifiers

DOI

10.1093/NEUONC/4.3.196

1 reference

4 August 2017

1 reference

4 August 2017

1 reference