(Q34750145)

4 August 2017

title

Redesigning allosteric activation in an enzyme (English)

1 reference

4 August 2017

Sadhna Rana

1

1 reference

4 August 2017

Nicola Pozzi

series ordinal

2

1 reference

4 August 2017

Leslie A Pelc

series ordinal

3

1 reference

4 August 2017

Enrico Di Cera

series ordinal

4

1 reference

4 August 2017

language of work or name

English

0 references

publication date

22 February 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

published in

1 reference

4 August 2017

volume

108

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4 August 2017

issue

13

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4 August 2017

page(s)

5221-5225

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Two mechanisms of ion selectivity in protein binding sites

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Engineering thrombin for selective specificity toward protein C and PAR1.

7 July 2018

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Combinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin Fold

7 July 2018

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Mutant N143P Reveals How Na+ Activates Thrombin

7 July 2018

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Stabilization of the E* Form Turns Thrombin into an Anticoagulant

7 July 2018

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The structure and function of G-protein-coupled receptors

7 July 2018

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Engineering Protein Allostery: 1.05 Å Resolution Structure and Enzymatic Properties of a Na+-activated Trypsin

7 July 2018

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7 July 2018

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Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels

7 July 2018

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Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

7 July 2018

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Role of Na+ and K+ in enzyme function

7 July 2018

1 reference

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A structural perspective on enzymes activated by monovalent cations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Redesigning the monovalent cation specificity of an enzyme

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Serine protease mechanism and specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The cation selectivity filter of the bacterial sodium channel, NaChBac

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Sodium binding site of factor Xa: role of sodium in the prothrombinase complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Site-specific dissection of substrate recognition by thrombin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The molecular environment of the Na+ binding site of thrombin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Structural basis of substrate specificity in the serine proteases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Conversion of thrombin into an anticoagulant by protein engineering

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Effect of monovalent cations on the pre-steady-state kinetic parameters of the plasma protease bovine activated protein C.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Kinetic mechanism for stimulation by monovalent cations of the amidase activity of the plasma protease bovine activated protein C.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

An introduction to molecular architecture and permeability of ion channels

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Alteration of ionic selectivity of a K+ channel by mutation of the H5 region

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Converting trypsin to chymotrypsin: the role of surface loops

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Thrombin is a Na(+)-activated enzyme

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The effect of metal ions on the amidolytic activity of human factor Xa (Activated Stuart-Prower Factor)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

Molecular dissection of Na+ binding to thrombin.

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Structural origins of substrate discrimination in trypsin and chymotrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Valence screening of water in protein crystals reveals potential Na+ binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Identification of strong modifications in cation selectivity in an Arabidopsis inward rectifying potassium channel by mutant selection in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Thermodynamics of Na+ binding to coagulation serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Dissecting substrate recognition by thrombin using the inactive mutant S195A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

Energetics of ion conduction through the K+ channel.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069170

The good, the bad and the ugly

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018860108

[Purification and properties of the beta-galactosidase (lactase) of Escherichia coli]

21 January 2018

1 reference

12 December 2020

Kinetic analysis of enzyme reactions. II. The potassium activation and calcium inhibition of pyruvic phosphoferase.

1 reference

12 December 2020

Role of residue Phe225 in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor VIIa

1 reference

12 December 2020

The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo

1 reference

12 December 2020

Identification of a binding site for quaternary amines in factor Xa

1 reference

12 December 2020

Role of the alpha-helix 163-170 in factor Xa catalytic activity

1 reference

12 December 2020

Release of fibrinopeptides by the slow and fast forms of thrombin

1 reference

12 December 2020

Identification and characterization of the sodium-binding site of activated protein C

1 reference

12 December 2020

Evidence that human alpha-thrombin is a monovalent cation-activated enzyme

1 reference

12 December 2020

Rational design of a potent anticoagulant thrombin

1 reference

12 December 2020

The Na+ binding site of thrombin

1 reference

12 December 2020

Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human coagulation factor xa. Studies on catalytic efficiency and inhibitor binding

1 reference

12 December 2020

Selective loss of fibrinogen clotting in a loop-less thrombin

1 reference

12 December 2020

Rapid kinetics of Na+ binding to thrombin

1 reference

12 December 2020

Kinetic studies of the role of monovalent cations in the amidolytic activity of activated bovine plasma protein C

1 reference

12 December 2020

Stimulation of the amidase and esterase activity of activated bovine plasma protein C by monovalent cations

1 reference

12 December 2020

Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity

1 reference

12 December 2020

Rational engineering of activity and specificity in a serine protease

1 reference

12 December 2020

High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form

1 reference

12 December 2020

Enzymes activated by monovalent cations

1 reference

12 December 2020

Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand

1 reference

12 December 2020

Molecular mapping of thrombin-receptor interactions

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1018860108

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference