(Q34918248)

5 August 2017

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title

Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (English)

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5 August 2017

2

Satoshi Omura

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5 August 2017

Hirofumi Nakano

1

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5 August 2017

9 January 2009

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The Journal of Antibiotics

5 August 2017

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5 August 2017

62

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5 August 2017

17-26

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5 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/ja.2008.4

5 August 2017

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The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

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Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton

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Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.

21 January 2018

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Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

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A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

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Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

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Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

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The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape

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The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

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Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy

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Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

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Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms

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The Serine/Threonine/Tyrosine Phosphoproteome of the Model BacteriumBacillus subtilis

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Staurosporine, a potentially important gift from a microorganism.

21 January 2018

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7 January 2021

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

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7 January 2021

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation

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7 January 2021

Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus

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Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccarothrix aerocolonigenes ATCC39243.

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7 January 2021

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

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7 January 2021

K-252a, a potent inhibitor of protein kinase C from microbial origin

1 reference

7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

7 January 2021

Salt form selection and characterization of LY333531 mesylate monohydrate

1 reference

7 January 2021

Identifiers

DOI

10.1038/JA.2008.4

1 reference

PubMed ID

19132059

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

19132059