(Q34954162)

5 August 2017

title

Targeting RNA binding proteins involved in neurodegeneration (English)

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5 August 2017

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Maurizio Romano

1

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5 August 2017

Emanuele Buratti

series ordinal

2

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5 August 2017

publication date

16 August 2013

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Journal of Biomolecular Screening

5 August 2017

published in

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5 August 2017

volume

18

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5 August 2017

issue

9

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5 August 2017

page(s)

967-983

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An extensive network of coupling among gene expression machines

5 August 2017

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RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration.

21 January 2018

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RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond

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Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

21 January 2018

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Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics

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Biomarkers in frontotemporal lobar degeneration

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TDP-43: gumming up neurons through protein-protein and protein-RNA interactions

21 January 2018

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Rodent models of TDP-43 proteinopathy: investigating the mechanisms of TDP-43-mediated neurodegeneration

21 January 2018

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TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology

21 January 2018

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Zebrafish models for the functional genomics of neurogenetic disorders

21 January 2018

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Drosophila Answers to TDP-43 Proteinopathies

21 January 2018

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Nervous yeast: modeling neurotoxic cell death

21 January 2018

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Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Stress granules as crucibles of ALS pathogenesis.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Strategies for the inhibition of protein aggregation in human diseases

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

21 January 2018

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Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

21 January 2018

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Does a loss of TDP-43 function cause neurodegeneration?

21 January 2018

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ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

21 January 2018

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A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

21 January 2018

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

21 January 2018

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Structural determinants of the cellular localization and shuttling of TDP-43.

21 January 2018

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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

21 January 2018

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Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

21 January 2018

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Mouse models of frontotemporal dementia

21 January 2018

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Rodent models of TDP-43: recent advances

21 January 2018

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

21 January 2018

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

A protein interaction framework for human mRNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

21 January 2018

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Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

21 January 2018

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Searching for the Holy Grail; protein-protein interaction analysis and modulation

21 January 2018

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Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

21 January 2018

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Modulators of protein-protein interactions: novel approaches in targeting protein kinases and other pharmaceutically relevant biomolecules

21 January 2018

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Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

21 January 2018

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The BioGRID interaction database: 2013 update

21 January 2018

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The IntAct molecular interaction database in 2012

21 January 2018

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The Comparative Toxicogenomics Database: update 2013.

21 January 2018

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Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Regulation of autophagy by neuropathological protein TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.

21 January 2018

1 reference

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Targeting RNA to treat neuromuscular disease

21 January 2018

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TDP-43: new aspects of autoregulation mechanisms in RNA binding proteins and their connection with human disease

21 January 2018

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TDP-43 autoregulation: implications for disease

21 January 2018

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Characterizing TDP-43 interaction with its RNA targets

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

TDP-43 regulates its mRNA levels through a negative feedback loop

21 January 2018

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Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.

21 January 2018

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Splicing modulation mediated by small nuclear RNAs as therapeutic approaches for muscular dystrophies.

21 January 2018

1 reference

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Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Gene expression profiling in human neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications

21 January 2018

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A human protein-protein interaction network: a resource for annotating the proteome

21 January 2018

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A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome.

21 January 2018

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Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

21 January 2018

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White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin.

21 January 2018

1 reference

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System-wide changes to SUMO modifications in response to heat shock

21 January 2018

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An atlas of combinatorial transcriptional regulation in mouse and man

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Systematic analysis of human protein complexes identifies chromosome segregation proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Purification and identification of endogenous polySUMO conjugates

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113497256

Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles

21 January 2018

1 reference

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Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Systematic and quantitative assessment of the ubiquitin-modified proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

A census of human soluble protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Large-scale mapping of human protein-protein interactions by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Antagonistic factors control the unproductive splicing of SC35 terminal intron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113497256

21 January 2018

Identifiers

DOI

10.1177/1087057113497256

1 reference

5 August 2017

1 reference