(Q34989790)

5 August 2017

1 reference

title

The genetic pathogenesis of colorectal cancer (English)

1 reference

5 August 2017

1 reference

1 reference

John P Lynch

1

1 reference

PubMed ID

12418049

5 August 2017

Timothy C Hoops

series ordinal

2

1 reference

5 August 2017

1 August 2002

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Hematology / Oncology Clinics of North America

5 August 2017

1 reference

5 August 2017

16

1 reference

5 August 2017

775-810

1 reference

5 August 2017

4

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Chemoprevention of colorectal cancer

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Combinatorial chemoprevention of intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

American Gastroenterological Association medical position statement: hereditary colorectal cancer and genetic testing

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

AGA technical review on hereditary colorectal cancer and genetic testing.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Blocking oncogenic Ras signaling for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Cyclooxygenase-2: a novel target for cancer chemotherapy?

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The cellular and molecular pathogenesis of colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Molecular pathogenesis of colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Colorectal polyps and their relationship to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Aberrant crypt foci of the colon as precursors of adenoma and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Aberrant crypt foci in human colons: distribution and histomorphologic characteristics

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Human aberrant crypt foci with carcinoma in situ from a patient with sporadic colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The multistep nature of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

1 reference

7 January 2021

A genetic model for colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic instability and darwinian selection in tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The evolution of cancer of the colon and rectum

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Cancer-susceptibility genes. Gatekeepers and caretakers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

An update on Lynch syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Somatically acquired genetic alterations in flat colorectal neoplasias.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Prevalence and distinctive biologic features of flat colorectal adenomas in a North American population

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Inflammatory bowel disease and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

p27 expression in inflammatory bowel disease-associated neoplasia. Further evidence of a unique molecular pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic instability in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic instabilities in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The genetics of cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mutations of mitotic checkpoint genes in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mammalian DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Eukaryotic DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

DNA repair and colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Deficient DNA mismatch repair: a common etiologic factor for colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mismatch repair, molecular switches, and signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Hypotensive mechanisms of amifostine

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Epigenetic gene silencing in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Epigenetic reprogramming in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Analysis of genomic imprinting of insulin-like growth factor 2 in colorectal cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

CpG island methylator phenotype in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Molecular diagnosis of familial adenomatous polyposis.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Linking colorectal cancer to Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

1 reference

7 January 2021

Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The APC tumour suppressor has a nuclear export function.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Casein kinase I transduces Wnt signals

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Identification of c-MYC as a target of the APC pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Signalling networks that cause cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Alterations of the PPP2R1B gene in human lung and colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

APC mutations in colorectal tumors with mismatch repair deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The APC gene product in normal and tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Activation of the beta-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Stabilization of beta-catenin by genetic defects in melanoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

A positive role for the PP2A catalytic subunit in Wnt signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Escherichia coli heat-stable enterotoxin receptors. A novel marker for colorectal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

MutS homologs in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

MutS mediates heteroduplex loop formation by a translocation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The molecular basis of Turcot's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

A role for MLH3 in hereditary nonpolyposis colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Familial endometrial cancer in female carriers of MSH6 germline mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Novel dominant mutations in Saccharomyces cerevisiae MSH6.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mouse models for colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

K-ras andp53 mutations in hereditary non-polyposis colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of theTGRβRII,BAX,hMSH3,hMSH6,IGFIIR andBLM genes

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mutations of E2F-4 trinucleotide repeats in colorectal cancer with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Microsatellite instability in cancer of the proximal colon

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Role of transforming growth factor-beta signaling in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Signaling of transforming growth factor-beta family members through Smad proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Does mutation of transforming growth factor-beta type II receptor gene play an important role in colorectal polyps?

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mad-related genes in the human

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Down-regulation of TGF-beta receptors in human colorectal cancer: implications for cancer development

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic alterations during colorectal-tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

MDM2: life without p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Regulation and function of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The p53 tumor suppressor gene: from molecular biology to clinical investigation.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Regulation of p53 function

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Regulation of p53 downstream genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

The p53-deficient mouse: a model for basic and applied cancer studies

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Cancer. p53, guardian of the genome

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Impact of KRAS and TP53 mutations on survival in patients with left- and right-sided Dukes' C colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: independent prognostic role of p53 and bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Virus-mediated killing of cells that lack p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

p53: a potential target antigen for immunotherapy of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Guanylyl cyclase-C receptor mRNA distribution along the rat nephron

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Ras and Rho regulation of the cell cycle and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Activating SRC mutation in a subset of advanced human colon cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

PPARgamma and colorectal carcinoma: conflicts in a nuclear family

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900029-1

7 January 2021

10.1016/S0889-8588(02)00029-1

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12418049