(Q34998152)

5 August 2017

title

The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans (English)

1 reference

5 August 2017

main subject

Caenorhabditis elegans

0 references

author name string

Pierre Haldimann

1

1 reference

5 August 2017

Maude Muriset

2

1 reference

5 August 2017

László Vígh

3

1 reference

5 August 2017

Pierre Goloubinoff

4

1 reference

5 August 2017

language of work or name

English

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publication date

6 April 2011

1 reference

Journal of Biological Chemistry

5 August 2017

published in

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5 August 2017

volume

286

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5 August 2017

issue

21

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5 August 2017

page(s)

18784-18794

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The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

5 August 2017

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The insulin paradox: aging, proteotoxicity and neurodegeneration

8 July 2018

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Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS

8 July 2018

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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

8 July 2018

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Adapting proteostasis for disease intervention

8 July 2018

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HSP72 protects against obesity-induced insulin resistance

8 July 2018

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Can the stress protein response be controlled by 'membrane-lipid therapy'?

8 July 2018

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Trinucleotide Repeat Disorders

8 July 2018

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Chaperones and proteases: cellular fold-controlling factors of proteins in neurodegenerative diseases and aging.

8 July 2018

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8 July 2018

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8 July 2018

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Opposing activities protect against age-onset proteotoxicity

8 July 2018

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Molecular chaperones and protein quality control

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

8 July 2018

1 reference

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Membrane-lipid therapy: a new approach in molecular medicine.

8 July 2018

1 reference

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Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Sick chaperones, cellular stress, and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Some like it hot: the structure and function of small heat-shock proteins.

8 July 2018

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8 July 2018

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Opinion: What is the role of protein aggregation in neurodegeneration?

8 July 2018

1 reference

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Heat shock response modulators as therapeutic tools for diseases of protein conformation

8 July 2018

1 reference

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A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Modulation of neurodegeneration by molecular chaperones

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans

8 July 2018

1 reference

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Experimental therapeutics in transgenic mouse models of Huntington's disease

8 July 2018

1 reference

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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Unfolding the role of protein misfolding in neurodegenerative diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Molecular chaperones in the cytosol: from nascent chain to folded protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Glutamine repeats and neurodegeneration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Direct observation of stress response in Caenorhabditis elegans using a reporter transgene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Glutamine repeats and neurodegenerative diseases: molecular aspects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

The genetics of Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099695

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

Timing requirements for insulin/IGF-1 signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.234773

Heat Shock Protein Accumulation Is Upregulated in a Long-Lived Mutant of Caenorhabditis elegans

21 January 2018

1 reference

12 December 2020

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

12 December 2020

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

1 reference

12 December 2020

Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1

1 reference

12 December 2020

The small heat-shock protein IbpB from Escherichia coli stabilizes stress-denatured proteins for subsequent refolding by a multichaperone network

1 reference

12 December 2020

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.234773

1 reference

5 August 2017

1 reference

5 August 2017

1 reference