(Q35019590)

5 August 2017

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title

Replicative senescence and senescence-like state induced in cancer-derived cells (English)

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5 August 2017

Eun Seong Hwang

1

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5 August 2017

publication date

1 November 2002

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Mechanisms of Ageing and Development

5 August 2017

published in

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5 August 2017

volume

123

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5 August 2017

issue

12

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5 August 2017

page(s)

1681-1694

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

5 August 2017

cites work

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

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7 January 2021

Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer

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7 January 2021

From cells to organisms: can we learn about aging from cells in culture?

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7 January 2021

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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7 January 2021

Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

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7 January 2021

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

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7 January 2021

Oxidative DNA damage and senescence of human diploid fibroblast cells.

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7 January 2021

p16 INK4a can initiate an autonomous senescence program

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7 January 2021

A highly selective telomerase inhibitor limiting human cancer cell proliferation

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7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

Comparative analysis of p73 and p53 regulation and effector functions

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7 January 2021

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

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7 January 2021

E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc

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7 January 2021

Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

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7 January 2021

Rapid induction of senescence in human cervical carcinoma cells

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7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

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7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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7 January 2021

The serial cultivation of human diploid cell strains

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7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

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7 January 2021

Expression of p16INK4a suppresses the unbounded and anchorage-independent growth of a glioblastoma cell line that lacks p16INK4a

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7 January 2021

Regulation of cellular senescence by p53.

1 reference

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7 January 2021

p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer

1 reference

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7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

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7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

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7 January 2021

Telomerase activation by the E6 gene product of human papillomavirus type 16.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Genes involved in senescence and immortalization

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7 January 2021

Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Evidence for the recessive nature of cellular immortality

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

A model for p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

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7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

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7 January 2021

A survey of telomerase activity in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress.

1 reference

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7 January 2021

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging

1 reference

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7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Inhibition of human telomerase by a G-quadruplex-interactive compound

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Sodium butyrate induces growth arrest and senescence-like phenotypes in gynecologic cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2'-deoxycytidine treatment induces a senescence-like state

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Mapping a novel cellular-senescence gene to human chromosome 2q37 by irradiation microcell-mediated chromosome transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Induction of senescence in human malignant glioma cells by p16INK4A.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Lipofuscin accumulation and ageing of fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

Replicative senescence, aging and growth-regulatory transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900102-1

7 January 2021

10.1016/S0047-6374(02)00102-1

Identifiers

DOI

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5 August 2017

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