(Q35030310)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

0 references

9

1 reference

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4 February 2020

Tobias Hartmann

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Matthias Riemenschneider

10

object named as

Matthias Riemenschneider

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

author name string

Marcus O W Grimm

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Sven Grösgen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Tatjana L Rothhaar

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Verena K Burg

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Benjamin Hundsdörfer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Viola J Haupenthal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Petra Friess

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Ulrike Müller

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Heike S Grimm

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

publication date

18 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

International journal of Alzheimer's disease

4 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

volume

2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

page(s)

695413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

4 February 2020

copyright license

start time

1 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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8 July 2018

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Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

8 July 2018

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Deregulation of sphingolipid metabolism in Alzheimer's disease

8 July 2018

1 reference

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Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review

8 July 2018

1 reference

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

8 July 2018

1 reference

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

8 July 2018

1 reference

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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

8 July 2018

1 reference

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Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

8 July 2018

1 reference

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Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

8 July 2018

1 reference

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Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

8 July 2018

1 reference

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Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

8 July 2018

1 reference

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Spatial segregation of gamma-secretase and substrates in distinct membrane domains

8 July 2018

1 reference

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Molecular biology and genetics of Alzheimer's disease

8 July 2018

1 reference

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Association of active gamma-secretase complex with lipid rafts.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

8 July 2018

1 reference

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The cell biology of glycosphingolipids.

8 July 2018

1 reference

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GM1 ganglioside regulates the proteolysis of amyloid precursor protein

8 July 2018

1 reference

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

8 July 2018

1 reference

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Cholesterol and the biology of Alzheimer's disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Signal transduction and the regulation of apoptosis: roles of ceramide

8 July 2018

1 reference

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

8 July 2018

1 reference

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

8 July 2018

1 reference

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Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

8 July 2018

1 reference

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

8 July 2018

1 reference

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

8 July 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

8 July 2018

1 reference

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Alzheimer's disease: beta-Amyloid protein and tau.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Ceramide and sphingomyelinases in the regulation of stress responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Ceramide in the eukaryotic stress response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Purification and cloning of amyloid precursor protein beta-secretase from human brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Signal transduction of stress via ceramide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Functional rafts in cell membranes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Deletion of an endosomal/lysosomal targeting signal promotes the secretion of Alzheimer's disease amyloid precursor protein (APP).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Sphingolipid metabolism and cell growth regulation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

New clues to Alzheimer's disease: unraveling the roles of amyloid and tau.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Measurement of protein using bicinchoninic acid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Amyloid plaque core protein in Alzheimer disease and Down syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

8 July 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

Formation of toxic Abeta(1-40) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: polymorphisms in Abeta(1-40) fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F695413

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

Human brain gangliosides in development, aging and disease

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109855

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21660213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4061/2011/695413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21660213%20AND%20SRC:MED&resulttype=core&format=json