(Q35049159)

6 August 2017

Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome (English)

1 reference

6 August 2017

2

Arieh Warshel

1 reference

6 August 2017

Andrew J Adamczyk

1

1 reference

PubMed ID

21617092

6 August 2017

language of work or name

English

0 references

publication date

26 May 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

1 reference

6 August 2017

108

1 reference

6 August 2017

9827-9832

1 reference

6 August 2017

24

1 reference

The Mechanism for Activation of GTP Hydrolysis on the Ribosome

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Renormalizing SMD: the renormalization approach and its use in long time simulations and accelerated PMF calculations of macromolecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

What recent ribosome structures have revealed about the mechanism of translation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

GTPase activation of elongation factor EF-Tu by the ribosome during decoding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Toward accurate screening in computer-aided enzyme design

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

The energetics of the primary proton transfer in bacteriorhodopsin revisited: it is a sequential light-induced charge separation after all

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Simulating the effect of DNA polymerase mutations on transition-state energetics and fidelity: evaluating amino acid group contribution and allosteric coupling for ionized residues in human pol beta

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Why does the Ras switch "break" by oncogenic mutations?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Recognition of cognate transfer RNA by the 30S ribosomal subunit

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Crystal structure of active elongation factor Tu reveals major domain rearrangements

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Site-directed mutagenesis of Thermus thermophilus elongation factor Tu. Replacement of His85, Asp81 and Arg300.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Structure-function relationships in the GTP binding domain of EF-Tu: mutation of Val20, the residue homologous to position 12 in p21

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116401

Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

From the structure and function of the ribosome to new antibiotics (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Unraveling the structure of the ribosome (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

The sarcin-ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

GTPase activation of elongation factors Tu and G on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Mutations in 23 S ribosomal RNA perturb transfer RNA selection and can lead to streptomycin dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

The importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Simulation and analysis of single-ribosome translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Substitution of histidine-84 and the GTPase mechanism of elongation factor Tu.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

What we have learned from ribosome structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

On the generation of catalytic antibodies by transition state analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

On the mechanism of hydrolysis of phosphate monoesters dianions in solutions and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

A fast estimate of electrostatic group contributions to the free energy of protein-inhibitor binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Multiscale simulations of protein landscapes: using coarse-grained models as reference potentials to full explicit models

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1105714108

Relevance of histidine-84 in the elongation factor Tu GTPase activity and in poly(Phe) synthesis: its substitution by glutamine and alanine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21617092

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutagenesis of three residues, isoleucine-60, threonine-61, and aspartic acid-80, implicated in the GTPase activity of Escherichia coli elongation factor Tu

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21617092

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1105714108

1 reference

release_lnyj4xf2bzfqdj3pd2efk4i6ye

6 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lnyj4xf2bzfqdj3pd2efk4i6ye

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3116401

1 reference

6 August 2017

1 reference

PubMed ID

21617092