(Q35109915)

6 August 2017

title

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity (English)

1 reference

6 August 2017

0 references

7

Susan Lindquist

1 reference

6 August 2017

Kent E S Matlack

1

1 reference

6 August 2017

Daniel F Tardiff

2

1 reference

6 August 2017

Priyanka Narayan

3

1 reference

6 August 2017

Shusei Hamamichi

4

1 reference

6 August 2017

Kim A Caldwell

5

1 reference

6 August 2017

Guy A Caldwell

6

1 reference

6 August 2017

language of work or name

English

0 references

publication date

3 March 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

6 August 2017

volume

111

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6 August 2017

issue

11

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6 August 2017

page(s)

4013-4018

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describes a project that uses

6 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3964050/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

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Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

9 July 2018

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9 July 2018

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9 July 2018

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Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms

9 July 2018

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Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

9 July 2018

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Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity

9 July 2018

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

9 July 2018

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

9 July 2018

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Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease

9 July 2018

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9 July 2018

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Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

9 July 2018

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

9 July 2018

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

9 July 2018

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9 July 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

9 July 2018

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Presenilin: running with scissors in the membrane

9 July 2018

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Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation.

9 July 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

9 July 2018

1 reference

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

9 July 2018

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

9 July 2018

1 reference

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

9 July 2018

1 reference

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Identification and characterization of a nerve terminal-enriched amphiphysin isoform

9 July 2018

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Rapid induction of Alzheimer A beta amyloid formation by zinc.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Genetics. Human genetic variation, shared and private

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Therapeutic redistribution of metal ions to treat Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964050

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24591589

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1402228111

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference