(Q35550995)

8 August 2017

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title

Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses (English)

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ubiquitin-proteasome system

8 August 2017

main subject

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3

Ted M Dawson

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8 August 2017

1

Darren J Moore

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8 August 2017

Valina L Dawson

2

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8 August 2017

publication date

1 January 2003

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8 August 2017

published in

NeuroMolecular Medicine

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8 August 2017

volume

4

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8 August 2017

issue

1-2

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8 August 2017

page(s)

95-108

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The 26S proteasome: a molecular machine designed for controlled proteolysis

8 August 2017

cites work

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12 December 2020

TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

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12 December 2020

Ubiquitin-mediated proteolysis: biological regulation via destruction

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12 December 2020

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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12 December 2020

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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12 December 2020

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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12 December 2020

Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

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12 December 2020

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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12 December 2020

Chaperone-like activity of synucleins

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12 December 2020

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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12 December 2020

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

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12 December 2020

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

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12 December 2020

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

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12 December 2020

Synphilin-1 is present in Lewy bodies in Parkinson's disease

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12 December 2020

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

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12 December 2020

Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease

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12 December 2020

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

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12 December 2020

Overview of the genetics of parkinsonism

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12 December 2020

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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12 December 2020

Altered proteasomal function in sporadic Parkinson's disease

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12 December 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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12 December 2020

Parkinson's disease. Second of two parts

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12 December 2020

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

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12 December 2020

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

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12 December 2020

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies

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12 December 2020

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

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12 December 2020

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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12 December 2020

Transferring substrates to the 26S proteasome.

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12 December 2020

Proteasomal function is impaired in substantia nigra in Parkinson's disease

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12 December 2020

A role for alpha-synuclein in the regulation of dopamine biosynthesis

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12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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12 December 2020

A large kindred with autosomal dominant Parkinson's disease

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12 December 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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12 December 2020

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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12 December 2020

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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12 December 2020

Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

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12 December 2020

Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation.

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12 December 2020

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

Genetic and environmental factors in the cause of Parkinson's disease

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12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

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12 December 2020

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

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12 December 2020

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

The parkin gene and its phenotype

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12 December 2020

Parkin and Parkinson's disease

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12 December 2020

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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12 December 2020

Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice

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12 December 2020

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

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12 December 2020

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients

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12 December 2020

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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12 December 2020

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

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12 December 2020

Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo

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12 December 2020

Degradation of alpha-synuclein by proteasome

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12 December 2020

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

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12 December 2020

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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12 December 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

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12 December 2020

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

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12 December 2020

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

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12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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12 December 2020

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12 December 2020

Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease

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12 December 2020

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

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12 December 2020

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12 December 2020

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

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12 December 2020

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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12 December 2020

The ubiquitin pathway in Parkinson's disease

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12 December 2020

Mechanisms underlying ubiquitination

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12 December 2020

Selective degradation of oxidatively modified protein substrates by the proteasome.

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

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12 December 2020

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

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12 December 2020

Alpha-synuclein and neurodegenerative diseases

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12 December 2020

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

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12 December 2020

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

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12 December 2020

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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12 December 2020

Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation

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12 December 2020

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.

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12 December 2020

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

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12 December 2020

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

Neuropathology of Parkinson's disease

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12 December 2020

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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12 December 2020

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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12 December 2020

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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12 December 2020

Pharmacological prevention of Parkinson disease in Drosophila.

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12 December 2020

Parkinson's disease. First of two parts

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12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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12 December 2020

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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12 December 2020

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

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12 December 2020

Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra

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12 December 2020

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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12 December 2020

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

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12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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12 December 2020

Identifiers

DOI

10.1385/NMM:4:1-2:95

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Dimensions Publication ID

8 August 2017

1012858536

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