(Q35558099)

English

Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors

scientific article published on April 2015

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scholarly article

1 reference

Europe PubMed Central

8 August 2017

Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors (English)

1 reference

Europe PubMed Central

8 August 2017

drug interaction

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Jayvardhan Pandit

object named as

Jayvardhan Pandit

21

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author name string

Michael A Brodney

1

1 reference

Europe PubMed Central

8 August 2017

Elizabeth M Beck

2

1 reference

Europe PubMed Central

8 August 2017

Christopher R Butler

3

1 reference

Europe PubMed Central

8 August 2017

Gabriela Barreiro

4

1 reference

Europe PubMed Central

8 August 2017

Eric F Johnson

5

1 reference

Europe PubMed Central

8 August 2017

David Riddell

6

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Europe PubMed Central

8 August 2017

Kevin Parris

7

1 reference

Europe PubMed Central

8 August 2017

Charles E Nolan

8

1 reference

Europe PubMed Central

8 August 2017

Ying Fan

9

1 reference

Europe PubMed Central

8 August 2017

Kevin Atchison

10

1 reference

Europe PubMed Central

8 August 2017

Cathleen Gonzales

11

1 reference

Europe PubMed Central

8 August 2017

Ashley E Robshaw

12

1 reference

Europe PubMed Central

8 August 2017

Shawn D Doran

13

1 reference

Europe PubMed Central

8 August 2017

Mark W Bundesmann

14

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8 August 2017

Leanne Buzon

15

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Europe PubMed Central

8 August 2017

Jason Dutra

16

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8 August 2017

Kevin Henegar

17

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Europe PubMed Central

8 August 2017

Erik LaChapelle

18

1 reference

Europe PubMed Central

8 August 2017

Xinjun Hou

19

1 reference

Europe PubMed Central

8 August 2017

Bruce N Rogers

20

1 reference

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8 August 2017

Ricardo Lira

22

1 reference

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8 August 2017

Luis Martinez-Alsina

23

1 reference

Europe PubMed Central

8 August 2017

Peter Mikochik

24

1 reference

Europe PubMed Central

8 August 2017

John C Murray

25

1 reference

Europe PubMed Central

8 August 2017

Kevin Ogilvie

26

1 reference

Europe PubMed Central

8 August 2017

Loren Price

27

1 reference

Europe PubMed Central

8 August 2017

Subas M Sakya

28

1 reference

Europe PubMed Central

8 August 2017

Aijia Yu

29

1 reference

Europe PubMed Central

8 August 2017

Yong Zhang

30

1 reference

Europe PubMed Central

8 August 2017

Brian T O'Neill

31

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Europe PubMed Central

8 August 2017

language of work or name

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publication date

1 April 2015

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Europe PubMed Central

8 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

8 August 2017

58

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Europe PubMed Central

8 August 2017

7

1 reference

Europe PubMed Central

8 August 2017

3223-3252

1 reference

Europe PubMed Central

8 August 2017

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Structural modifications that alter the P-glycoprotein efflux properties of compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

1 reference

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12 July 2018

Aminodifluorosulfinium salts: selective fluorination reagents with enhanced thermal stability and ease of handling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Predicting and tuning physicochemical properties in lead optimization: amine basicities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

The APP family of proteins: similarities and differences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Medicinal chemistry of hERG optimizations: Highlights and hang-ups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

hERG potassium channels and cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Drug-induced prolongation of the QT interval

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

12 July 2018

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

26 September 2018

Lipophilic efficiency: the most important efficiency metric in medicinal chemistry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

26 September 2018

Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses

1 reference

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26 September 2018

A quantitative assessment of hERG liability as a function of lipophilicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

26 September 2018

Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415909

26 September 2018

A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.

1 reference

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26 September 2018

Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance.

1 reference

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26 September 2018

A practical approach to the synthesis of 2,4-disubstituted oxazoles from amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/25781223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25781223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A concise synthesis of the octalactins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25781223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/25781223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.JMEDCHEM.5B00191

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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