(Q35652038)

9 August 2017

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title

Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery (English)

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9 August 2017

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Hye Jin Jung

1

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9 August 2017

Ho Jeong Kwon

series ordinal

2

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9 August 2017

publication date

4 June 2015

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Archives of Pharmacal Research

9 August 2017

published in

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9 August 2017

volume

38

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9 August 2017

issue

9

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9 August 2017

page(s)

1627-1641

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https://scigraph.springernature.com/pub.10.1007/s12272-015-0618-3

9 August 2017

exact match

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From drug to protein: using yeast genetics for high-throughput target discovery

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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Generation of improved humanized mouse models for human infectious diseases

21 January 2018

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An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

21 January 2018

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Natural products as chemical probes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis

21 January 2018

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Drug-target interaction prediction by random walk on the heterogeneous network

21 January 2018

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Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

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Identification and validation of bioactive small molecule target through phenotypic screening

21 January 2018

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Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance

21 January 2018

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Exploring Gene Function and Drug Action Using Chemogenomic Dosage Assays

21 January 2018

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The intermediate filament protein vimentin is a new target for epigallocatechin gallate

21 January 2018

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STRING v9.1: protein-protein interaction networks, with increased coverage and integration

21 January 2018

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Target identification of small molecules based on chemical biology approaches

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

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Genomic profiling of drug sensitivities via induced haploinsufficiency.

21 January 2018

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EnrichNet: network-based gene set enrichment analysis.

21 January 2018

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

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Patient-derived xenograft models: an emerging platform for translational cancer research

21 January 2018

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A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

21 January 2018

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An integrated approach for identification and target validation of antifungal compounds active against Erg11p

21 January 2018

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Identification of a primary target of thalidomide teratogenicity

21 January 2018

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Exploring the role of mitochondrial UQCRB in angiogenesis using small molecules

21 January 2018

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Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing

21 January 2018

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Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.

21 January 2018

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Ion channels as drug targets: the next GPCRs

21 January 2018

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KEGG for integration and interpretation of large-scale molecular data sets

21 January 2018

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Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics.

21 January 2018

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The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

21 January 2018

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Predicting new molecular targets for known drugs

21 January 2018

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Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

A robustness-based approach to systems-oriented drug design.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Targeting the cancer kinome through polypharmacology

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Discovery of new small molecules and targets towards angiogenesis via chemical genomics approach

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Target identification using drug affinity responsive target stability (DARTS)

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Towards high-throughput characterization of small molecule mechanisms of action

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

HLA class II transgenic mice mimic human inflammatory diseases.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Drug-target and disease networks: polypharmacology in the post-genomic era.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

CytoCom: a Cytoscape app to visualize, query and analyse disease comorbidity networks

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Quantitative chemical proteomics for identifying candidate drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Mass spectrometry-based proteomics turns quantitative

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Phage display systems and their applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Rapid identification of a protein binding partner for the marine natural product kahalalide F by using reverse chemical proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Applications of Connectivity Map in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Bugs, drugs and chemical genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Development and application of high-performance affinity beads: toward chemical biology and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Biochemical target isolation for novices: affinity-based strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

The cloning of human genes using cDNA phage display and small-molecule chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Target identification and mechanism of action in chemical biology and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Bioinformatic analysis of proteomics data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Chemical genetics resulting from a passion for synthetic organic chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Patient-derived tumor xenografts: transforming clinical samples into mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Proteomic methods for drug target discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Exploring biology with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

DTome: a web-based tool for drug-target interactome construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

How were new medicines discovered?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Using transcriptome sequencing to identify mechanisms of drug action and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Predicting drug-target interactions using restricted Boltzmann machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Novel computational approaches to polypharmacology as a means to define responses to individual drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

FR177391, a new anti-hyperlipidemic agent from Serratia. IV. Target identification and validation by chemical genetic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

New insights into chemical biology from ORFeome libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

Target identification for small bioactive molecules: finding the needle in the haystack

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0618-3

10.1007/S12272-015-0618-3

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference