(Q35668723)

English

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization

scientific article published on 15 November 2011

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization (English)

1 reference

Europe PubMed Central

9 August 2017

ATP binding cassette subfamily A member 2

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

regulation of protein localization to cell surface

1 reference

GOA release 2020-03-11

ATP-binding cassette sub-family A member 2

1 reference

GOA release 2020-03-11

Bart De Strooper

10

object named as

Bart De Strooper

1 reference

Europe PubMed Central

9 August 2017

Danyelle M Townsend

7

object named as

Danyelle M Townsend

1 reference

Europe PubMed Central

9 August 2017

8

object named as

Kenneth D Tew

1 reference

Europe PubMed Central

9 August 2017

author name string

Vasiliki Michaki

1

1 reference

Europe PubMed Central

9 August 2017

Francesc X Guix

2

1 reference

Europe PubMed Central

9 August 2017

Krist'l Vennekens

3

1 reference

Europe PubMed Central

9 August 2017

Sebastian Munck

4

1 reference

Europe PubMed Central

9 August 2017

Colin Dingwall

5

1 reference

Europe PubMed Central

9 August 2017

John B Davis

6

1 reference

Europe PubMed Central

9 August 2017

Fabian Feiguin

9

1 reference

Europe PubMed Central

9 August 2017

Carlos G Dotti

11

1 reference

Europe PubMed Central

9 August 2017

Tina Wahle

12

1 reference

Europe PubMed Central

9 August 2017

language of work or name

0 references

publication date

15 November 2011

1 reference

Europe PubMed Central

9 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

9 August 2017

287

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Europe PubMed Central

9 August 2017

2

1 reference

Europe PubMed Central

9 August 2017

1100-1111

1 reference

Europe PubMed Central

9 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3256850/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Membrane rafts in Alzheimer's disease beta-amyloid production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

S-palmitoylation of gamma-secretase subunits nicastrin and APH-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

1 reference

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27 July 2018

Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels

1 reference

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27 July 2018

Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production

1 reference

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Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking

1 reference

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27 July 2018

Culturing hippocampal neurons

1 reference

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27 July 2018

The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Palmitoylation: policing protein stability and traffic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

"Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Notch signalling in vertebrate neural development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Neuronal membrane cholesterol loss enhances amyloid peptide generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Association of ABCA2 expression with determinants of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Axonal neuregulin-1 regulates myelin sheath thickness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Intra-Golgi Protein Transport Depends on a Cholesterol Balance in the Lipid Membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

A cell biological perspective on Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

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27 July 2018

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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Alzheimer's disease: genes, proteins, and therapy

1 reference

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Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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An inventory of the human ABC proteins

1 reference

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Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

27 July 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

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The Niemann-Pick C lesion and its relationship to the intracellular distribution and utilization of LDL cholesterol

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A clinical staging classification for type C Niemann-Pick disease.

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Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex

1 reference

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The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation

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Contralateral leg as a control during skeletal muscle ischemia-reperfusion

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Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease

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Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

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1 reference

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Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells

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Neuregulins and the neuromuscular system: 10 years of answers and questions

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25 September 2018

A reporter for amyloid precursor protein gamma-secretase activity in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

25 September 2018

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

25 September 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

1 reference

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25 September 2018

The human ATP-binding cassette (ABC) transporter superfamily.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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ABC transporters and cholesterol metabolism

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256850

25 September 2018

Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.288258

21 January 2018

Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086926

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABCA2 as a therapeutic target in cancer and nervous system disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086926

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type C Niemann-Pick disease: spectrum of phenotypic variation in disruption of intracellular LDL-derived cholesterol processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086926

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.288258

1 reference

Europe PubMed Central

9 August 2017

release_o2mxr74w4vcdpogvitxi52huly

1 reference

https://api.fatcat.wiki/v0/release/o2mxr74w4vcdpogvitxi52huly

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

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