(Q35917530)

11 August 2017

1 reference

title

Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance (English)

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11 August 2017

Matthias Götte

1

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11 August 2017

publication date

1 October 2004

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Expert Review of Anti-infective Therapy

11 August 2017

published in

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11 August 2017

volume

2

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11 August 2017

issue

5

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11 August 2017

page(s)

707-716

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The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase

11 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Antiviral drugs in current clinical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

A model for the mechanism of polymerase translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

DNA polymerases: structural diversity and common mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Influence of reverse transcriptase variants, drugs, and Vpr on human immunodeficiency virus type 1 mutant frequencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovir-naive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mechanism of action of foscarnet against viral polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

A new potent HIV-1 reverse transcriptase inhibitor. A synthetic peptide derived from the interface subunit domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

Crystals of HIV-1 Reverse Transcriptase Diffracting to 2·2 Å Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789072.2.5.707

21 January 2018

Identifiers

DOI

10.1586/14789072.2.5.707

1 reference

11 August 2017

1 reference