(Q36244148)

13 August 2017

title

Screening-based approaches to identify small molecules that inhibit protein-protein interactions (English)

1 reference

protein-protein interaction

13 August 2017

main subject

1 reference

Sehee Choi

1

1 reference

13 August 2017

Kang-Yell Choi

series ordinal

2

1 reference

13 August 2017

language of work or name

English

0 references

publication date

8 January 2017

1 reference

Expert Opinion on Drug Discovery

13 August 2017

published in

1 reference

13 August 2017

volume

12

1 reference

13 August 2017

issue

3

1 reference

13 August 2017

page(s)

293-303

1 reference

STRING v10: protein-protein interaction networks, integrated over the tree of life

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Network medicine: a network-based approach to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

From protein interaction networks to novel therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Structural biology and drug discovery for protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Inhibitors of protein-protein interactions: new methodologies to tackle this challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

A leap into the chemical space of protein-protein interaction inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Modulators of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Antibodies as therapeutic agents: vive la renaissance!

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Can emerging drug classes improve R&D productivity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Protein-protein interactions as druggable targets: recent technological advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Peptide modulators of protein-protein interactions in intracellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Modulating protein-protein interactions: the potential of peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Synthetic therapeutic peptides: science and market

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small molecules, big targets: drug discovery faces the protein-protein interaction challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Alternative modulation of protein-protein interactions by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Oncogenic protein interfaces: small molecules, big challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Protein–protein docking benchmark version 4.0

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Cancer: Drug for an 'undruggable' protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

The Contribution of Missense Mutations in Core and Rim Residues of Protein-Protein Interfaces to Human Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Flexibility and small pockets at protein-protein interfaces: New insights into druggability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Predicting the Impact of Missense Mutations on Protein-Protein Binding Affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Predicting Binding Free Energy Change Caused by Point Mutations with Knowledge-Modified MM/PBSA Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Hot spots in protein-protein interfaces: towards drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Radiolabeled tirofiban - a potential radiopharmaceutical for detection of deep venous thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Drugging the undruggable RAS: Mission possible?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small-molecule modulation of Ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Verteporfin, a suppressor of YAP-TEAD complex, presents promising antitumor properties on ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

HTS promiscuity analyses for accelerating decision making

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Impact of high-throughput screening in biomedical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Methods for the elucidation of protein-small molecule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Fluorescence polarization/anisotropy in diagnostics and imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Fluorescence polarization assays in small molecule screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Screening in a spirit haunted world

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Application of fluorescence resonance energy transfer in protein studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

The use of resonance energy transfer in high-throughput screening: BRET versus FRET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Engineering of weak helper interactions for high-efficiency FRET probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

The use of AlphaScreen technology in HTS: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Chemistry: Chemical con artists foil drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Bridging the past and the future of virology: surface plasmon resonance as a powerful tool to investigate virus/host interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Surface plasmon resonance spectroscopy for characterisation of membrane protein-ligand interactions and its potential for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Spectral surface plasmon resonance imaging for the detection of clenbuterol via three-dimensional immobilization of bioprobes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Chemical library screening using a SPR-based inhibition in solution assay: simulations and experimental validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Bimodal imprint chips for peptide screening: integration of high-throughput sequencing by MS and affinity analyses by surface plasmon resonance imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Understanding ForteBio's Sensors for High-Throughput Kinetic and Epitope Screening for Purified Antibodies and Yeast Culture Supernatant

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Isothermal titration calorimetry of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

The thermodynamics of protein interactions with essential first row transition metals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Isothermal titration calorimetry for studying protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

De novo fragment design: a medicinal chemistry approach to fragment-based lead generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

High-throughput X-ray crystallography for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Discovering novel ligands for macromolecules using X-ray crystallographic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

The protein common interface database (ProtCID)--a comprehensive database of interactions of homologous proteins in multiple crystal forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Fragment screening using X-ray crystallography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Immunoprecipitation of Cdk-Cyclin Complexes for Determination of Kinase Activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Identification of novel proteins associated with both alpha-synuclein and DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Isolation of proteins and protein complexes by immunoprecipitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Hot spots--a review of the protein-protein interface determinant amino-acid residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Finding the rules for successful drug optimisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Drug-likeness analysis of traditional Chinese medicines: prediction of drug-likeness using machine learning approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Physicochemical profiling (solubility, permeability and charge state).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Paclitaxel and its formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Property-based design: optimization of drug absorption and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Quantitative structure-activity relationship: promising advances in drug discovery platforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Lead- and drug-like compounds: the rule-of-five revolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1280456

10.1080/17460441.2017.1280456

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference