(Q35738960)

10 August 2017

1 reference

title

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors (English)

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protein-protein interaction

10 August 2017

main subject

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Chunquan Sheng

1

1 reference

10 August 2017

Guoqiang Dong

2

1 reference

10 August 2017

Zhenyuan Miao

3

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10 August 2017

Wannian Zhang

4

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10 August 2017

Wei Wang

5

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10 August 2017

publication date

6 August 2015

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10 August 2017

published in

Chemical Society Reviews

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10 August 2017

volume

44

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10 August 2017

issue

22

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10 August 2017

page(s)

8238-8259

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Estimating the size of the human interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

An empirical framework for binary interactome mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Between a rock and a hard place?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Drugs targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Drug-like inhibitors of protein-protein interactions: a structural examination of effective protein mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Protein-protein interactions in receptor activation and intracellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Principles of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

The atomic structure of protein-protein recognition sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structural biology and drug discovery for protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Hot spots--a review of the protein-protein interface determinant amino-acid residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Binding of small molecules to an adaptive protein-protein interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

What induces pocket openings on protein surface patches involved in protein-protein interactions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Convergent solutions to binding at a protein-protein interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

In silico-in vitro screening of protein-protein interactions: towards the next generation of therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of modulators of protein-protein interactions: current approaches and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting protein-protein interaction by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small molecule modulators of protein-protein interactions: selected case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Modulators of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Protein-protein interactions as druggable targets: recent technological advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A leap into the chemical space of protein-protein interaction inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting protein-protein interactions and fragment-based drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Druggable protein-protein interactions--from hot spots to hot segments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting protein-protein interactions as an anticancer strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Oncogenic protein interfaces: small molecules, big challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Anatomy of hot spots in protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structural plasticity in a remodeled protein-protein interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structural conservation of druggable hot spots in protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Minimal ensembles of side chain conformers for modeling protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Hydrophobic Binding Hot Spots of Bcl-xL Protein-Protein Interfaces by Cosolvent Molecular Dynamics Simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Long-timescale molecular dynamics simulations of protein structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Locating and characterizing binding sites on proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Druggability indices for protein targets derived from NMR-based screening data

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Predicting druggable binding sites at the protein-protein interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Hot spots and transient pockets: predicting the determinants of small-molecule binding to a protein-protein interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Druggability assessment of protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Identification of small-molecule inhibitors of the JIP-JNK interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of small-molecule inhibitors of the TLR1/TLR2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Cancer: Drug for an 'undruggable' protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A decade of fragment-based drug design: strategic advances and lessons learned

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Library design for fragment based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Integration of fragment screening and library design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Theory and applications of NMR-based screening in pharmaceutical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Tethering: fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based lead discovery using X-ray crystallography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment library screening and lead characterization using SPR biosensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

SPR-based fragment screening: advantages and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

The rise of fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Recent developments in fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragonomics: fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Using fragment-based technologies to target protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Ligand efficiency and fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of low-molecular-weight ligands for the AF6 PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Inhibition of CDC25B phosphatase through disruption of protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based drug discovery: what really works. An interview with Sandy Farmer of Boehringer Ingelheim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Antagonists of protein-protein interactions made easy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Place your BETs: the therapeutic potential of bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Selective small molecules blocking HIV-1 Tat and coactivator PCAF association

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Target structure-based discovery of small molecules that block human p53 and CREB binding protein association

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure-based virtual screening for drug discovery: a problem-centric review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

State-of-the-art in ligand-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure-based design of small-molecule protein-protein interaction modulators: the story so far.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Virtual screening for compounds that mimic protein-protein interface epitopes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragmenting the S100B-p53 interaction: combined virtual/biophysical screening approaches to identify ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Thienoquinolines as novel disruptors of the PKCε/RACK2 protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure-based design of potent non-peptide MDM2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Efficient drug lead discovery and optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Inhibition of protein-protein interactions using designed molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Non-peptidic α-helical mimetics as protein-protein interaction inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Assessing helical protein interfaces for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Comprehensive peptidomimetic libraries targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Synthetic non-peptide mimetics of alpha-helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Pharmacophore identification of c-Myc inhibitor 10074-G5

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Diversity-oriented synthesis: producing chemical tools for dissecting biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Towards the optimal screening collection: a synthesis strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Route to three-dimensional fragments using diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Bioactivity-guided navigation of chemical space

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Natural product–inspired cascade synthesis yields modulators of centrosome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Biology-Oriented Synthesis of a Withanolide-Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Multicomponent reaction design in the quest for molecular complexity and diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Facile construction of structurally diverse thiazolidinedione-derived compounds via divergent stereoselective cascade organocatalysis and their biological exploratory studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Differences between high- and low-affinity complexes of enzymes and nonenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Structural properties of non-traditional drug targets present new challenges for virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Identifying and characterizing binding sites and assessing druggability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Study of the insulin dimerization: binding free energy calculations and per-residue free energy decomposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Transient Pockets on Protein Surfaces Involved in Protein−Protein Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

Molecular diversity by design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00252D

21 January 2018

Identifiers

DOI

10.1039/C5CS00252D

1 reference

10 August 2017

1 reference