(Q36346828)

13 August 2017

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title

Phosphoinositide 3-kinase: from viral oncoprotein to drug target (English)

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13 August 2017

Peter K Vogt

1

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author name string

Andreas G Bader

series ordinal

2

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PubMed ID

16364744

13 August 2017

Sohye Kang

series ordinal

3

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PubMed ID

16364744

13 August 2017

language of work or name

English

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publication date

1 January 2006

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13 August 2017

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13 August 2017

344

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13 August 2017

131-138

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13 August 2017

1

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Role of translocation in the activation and function of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

The akt kinase: molecular determinants of oncogenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

The PIK3CA gene is mutated with high frequency in human breast cancers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Mutation of the PIK3CA gene in ovarian and breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

The phosphoinositide 3-kinase pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Isolation of three new avian sarcoma viruses: ASV 9, ASV 17, and ASV 25

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Translational regulation by Y-box transcription factor: involvement of the major mRNA-associated protein, p50.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

7 January 2021

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PIK3CA mutations in glioblastoma multiforme.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Upstream and downstream of mTOR

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Functional analysis of PIK3CA gene mutations in human colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

The pleiotropic functions of the Y-box-binding protein, YB-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Mutations of PIK3CA in gastric adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rheb binds and regulates the mTOR kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PIK3CA as an oncogene in cervical cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Avian sarcoma virus 17 carries the jun oncogene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

In situ click chemistry: enzyme inhibitors made to their own specifications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PI3K in lymphocyte development, differentiation and activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

High frequency of mutations of the PIK3CA gene in human cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rheb promotes cell growth as a component of the insulin/TOR signalling network

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PIK3CA is implicated as an oncogene in ovarian cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Monoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Signaling by distinct classes of phosphoinositide 3-kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Phosphoinositide 3-kinases: a conserved family of signal transducers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Structural insights into phosphoinositide 3-kinase catalysis and signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

PIK3CA mutations in advanced ovarian carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Phosphoinositide 3-kinase signalling--which way to target?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

7 January 2021

Structure and transforming function of transduced mutant alleles of the chicken c-myc gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

7 January 2021

Analysis of a deleted MC29 provirus: gag sequences are not required for fibroblast transformation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

7 January 2021

The membrane-binding domain of the Rous sarcoma virus Gag protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2005.09.027

7 January 2021

10.1016/J.VIROL.2005.09.027

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16364744