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How the Bcl-2 family of proteins interact to regulate apoptosis.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
How the Bcl-2 family of proteins interact to regulate apoptosis
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
main subject
apoptotic process
0 references
protein family
1 reference
based on heuristic
inferred from title
author
Mark F van Delft
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
David C Huang
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
author name string
David C S Huang
series ordinal
2
1 reference
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Europe PubMed Central
PubMed ID
16474435
retrieved
13 August 2017
language of work or name
English
1 reference
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publication date
1 February 2006
1 reference
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Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
published in
Cell Research
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
volume
16
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
page(s)
203-213
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cr.7310028
0 references
cites work
Ways of dying: multiple pathways to apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell death: critical control points
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Bcl-2 family: roles in cell survival and oncogenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse models of cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Testicular degeneration in Bclw-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of apoptosis: uncovering the binding determinants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of the antiapoptotic protein bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-Only proteins-essential initiators of apoptotic cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PUMA, a novel proapoptotic gene, is induced by p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PUMA induces the rapid apoptosis of colorectal cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integral role of Noxa in p53-mediated apoptotic response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bad-deficient mice develop diffuse large B cell lymphoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Bax: coregulation of dimer formation and intracellular localization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Movement of Bax from the cytosol to mitochondria during apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
VDAC2 inhibits BAK activation and mitochondrial apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MAP-1 is a mitochondrial effector of Bax.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pathophysiology of mitochondrial cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial control of cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BID: a novel BH3 domain-only death agonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational control in stress and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis: a link between cancer genetics and chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surfing the p53 network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A view to a kill: ligands for Bcl-2 family proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CR.7310028
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CR.7310028
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PubMed ID
16474435
1 reference
stated in
Europe PubMed Central
PubMed ID
16474435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16474435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
ResearchGate publication ID
7303078
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