(Q36476116)

14 August 2017

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title

Rescue of folding defects in ABC transporters using pharmacological chaperones (English)

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14 August 2017

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Tip W Loo

1

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14 August 2017

M Claire Bartlett

series ordinal

2

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14 August 2017

David M Clarke

series ordinal

3

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14 August 2017

publication date

1 December 2005

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Journal of Bioenergetics and Biomembranes

14 August 2017

published in

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14 August 2017

volume

37

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14 August 2017

issue

6

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14 August 2017

page(s)

501-507

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Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

14 August 2017

cites work

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12 December 2020

Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target

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12 December 2020

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

1 reference

12 December 2020

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

12 December 2020

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

1 reference

12 December 2020

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

1 reference

12 December 2020

P-glycoprotein. Associations between domains and between domains and molecular chaperones

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12 December 2020

A conditional mutation affecting localization of the Menkes disease copper ATPase. Suppression by copper supplementation.

1 reference

12 December 2020

Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

1 reference

12 December 2020

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

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12 December 2020

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

12 December 2020

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

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12 December 2020

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

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12 December 2020

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

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12 December 2020

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

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12 December 2020

The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator

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12 December 2020

Epithelial cell dysfunction in cystic fibrosis: implications for airways disease

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12 December 2020

Nonylphenol ethoxylates, but not nonylphenol, are substrates of the human multidrug resistance P-glycoprotein

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12 December 2020

Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells

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12 December 2020

Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.

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12 December 2020

Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor

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12 December 2020

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

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12 December 2020

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

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12 December 2020

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

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12 December 2020

Macromolecular interactions and ion transport in cystic fibrosis

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12 December 2020

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

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12 December 2020

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

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12 December 2020

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

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12 December 2020

Recombinant N-terminal nucleotide-binding domain from mouse P-glycoprotein. Overexpression, purification, and role of cysteine 430

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12 December 2020

Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis

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12 December 2020

Identification of a splice site mutation (2789 +5 G > A) associated with small amounts of normal CFTR mRNA and mild cystic fibrosis

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12 December 2020

Recovering antibody secretion using a hapten ligand as a chemical chaperone.

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12 December 2020

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

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12 December 2020

Overexpression and purification of the carboxyl-terminal nucleotide-binding domain from mouse P-glycoprotein. Strategic location of a tryptophan residue.

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12 December 2020

Mistargeted MRPdeltaF728 mutant is rescued by intracellular GSH.

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12 December 2020

Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland

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12 December 2020

Proper folding and endoplasmic reticulum to golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine

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12 December 2020

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

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12 December 2020

The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy

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12 December 2020

Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA

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12 December 2020

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

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12 December 2020

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

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12 December 2020

CFTR in cystic fibrosis and cholera: from membrane transport to clinical practice

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12 December 2020

Curcumin does not stimulate cAMP-mediated chloride transport in cystic fibrosis airway epithelial cells

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12 December 2020

Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

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12 December 2020

Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein

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12 December 2020

Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited

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12 December 2020

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

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12 December 2020

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

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12 December 2020

Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains.

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12 December 2020

Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure

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12 December 2020

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

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12 December 2020

Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells

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12 December 2020

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

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12 December 2020

Ligand binding is a critical requirement for plasma membrane expression of heteromeric kainate receptors

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12 December 2020

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

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12 December 2020

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

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12 December 2020

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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12 December 2020

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

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12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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12 December 2020

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

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12 December 2020

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

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12 December 2020

The Engine of ABC Proteins

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12 December 2020

Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

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12 December 2020

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

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12 December 2020

Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein

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12 December 2020

Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound

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12 December 2020

Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism

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12 December 2020

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

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12 December 2020

Increased functional cell surface expression of CFTR and DeltaF508-CFTR by the anthracycline doxorubicin

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12 December 2020

Functional characterization of Candida albicans ABC transporter Cdr1p.

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12 December 2020

Mutational analysis of ABCG2: role of the GXXXG motif

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12 December 2020

Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients.

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12 December 2020

Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein

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12 December 2020

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

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12 December 2020

10.1007/S10863-005-9499-3

Identifiers

DOI

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14 August 2017

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